Document Detail


Changes in serum biochemical responses during cardiac rehabilitation.
MedLine Citation:
PMID:  12750582     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The objective of the study was to establish the difference in the exercise response profile of the enzymes lactate dehydrogenase (LDH), lactate dehydrogenase isoenzyme 1 (LDH-1), creatine kinase (CK), and creatine kinase polypeptide subunit MB (CK-MB) after a 12-wk cardiac rehabilitation exercise program. METHODS: Nineteen male nonblockade recent postmyocardial infarction patients (PMIP), aged 60.7 +/- 6.5 yr, performed a graded exercise test on a motorized treadmill until volitional cessation or reaching any of the American College of Sports Medicine criteria. After this, a 12-wk exercise-based cardiac rehabilitation program was adopted at a frequency of 3x wk-1. Each subject was then retested using the same protocol and intensity. Blood samples were collected by venipuncture from the antecubital vein into Vacutainer tubes preexercise, immediately, postexercise, and 24 h later. The blood samples were then centrifuged to obtain serum before being transported to the laboratory for enzymatic analysis by conventional methods. RESULTS: a) a 12-wk cardiac rehabilitation exercise program had no influence on the serum activities of enzymes at rest; b) the same exercise reduced the enzyme activity level after training; and c) LDH and CK values returned to normal faster after the program. CONCLUSIONS: These findings provide further evidence for the benefits of exercise-based cardiac rehabilitation and demonstrate that an exercise test provokes a temporary serum enzyme response, which does not reflect myocardial damage.
Authors:
David A Brodie; Xun Liu; Malcolm Jackson
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  35     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-16     Completed Date:  2003-08-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  741-6     Citation Subset:  IM; S    
Affiliation:
Research Centre for Health Studies, Buckinghamshire Chilterns University College, Buckinghamshire, United Kingdom. david.brodie@bcucc.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Aspartate Aminotransferases / metabolism*
Biological Markers / blood
Clinical Enzyme Tests
Creatine Kinase / metabolism*
Electrocardiography
Exercise Test
Humans
Isoenzymes / metabolism*
L-Lactate Dehydrogenase / metabolism*
Male
Middle Aged
Myocardial Infarction / diagnosis,  enzymology*,  rehabilitation*
Probability
Prognosis
Prospective Studies
Risk Assessment
Sampling Studies
Sensitivity and Specificity
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.27.-/lactate dehydrogenase 1; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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