| Changes in the sensitivity of adrenergic receptors in the oviduct during early gestation in the rabbit. | |
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MedLine Citation:
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PMID: 1269807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is evidence to indicate that the transport of an egg through the rabbit oviduct is controlled through an interaction of the sympathetic nervous system and ovarian hormones. The effect of norepinephrine (NE) on the contractility of the oviduct during the first 8 days of gestation was studied using the rabbit perfused oviduct. The sensitivity of the alpha-adrenergic receptors of the oviduct to NE decreased progressively during early gestation. This was reflected in a potency change and a decrease in the maximal response obtained. These data support the concept that an isthmic sphinctering effect mediated by the autonomic nervous system may play a role in the regulation of egg transport through the oviduct. Blood pressure responses to NE did not change during early pregnancy except that the responses to NE were significantly enhanced immediately after mating. This suggests that the sensitivity changes to autonomic agents during early gestation may be selective for reproductive tissues. The effect of norepinephrine (NE) on the contractility of the perfused oviduct was studied during the 1st 8 days of gestation in the rabbit. During early gestation, the sensitivity of the alpha-adrenergic receptors of the oviduct progressively decreased, the change being reflected by a change in potency and a decrease in the maximal response. Carotid artery blood pressure was significantly increased immediately after mating (p less than .05), though the responses returned to normal during early pregnancy. The results support the hypothesis that the regulation of egg transport through the oviduct may be influenced by an isthmic sphinctering effect mediated by the autonomic nervous system. It is suggested that the response changes to autonomic agents during early pregnancy may be selective for reproductive tissue. |
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Authors:
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R D Heilman; R R Reo; D W Hahn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 27 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1976 Apr |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 426-30 Citation Subset: IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dose-Response Relationship, Drug Fallopian Tubes / drug effects* Female Muscle Contraction / drug effects Norepinephrine / pharmacology* Ovum Transport / drug effects Pregnancy Rabbits Receptors, Adrenergic / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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