Document Detail


Changes in secretory status, cell height and percentage ciliation of epithelial lining of sheep fimbria oviduct during early pregnancy.
MedLine Citation:
PMID:  8699399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies have shown that the biosynthetic activity of the fimbria oviduct in the sheep changes during the first few weeks of pregnancy. The objective of the present study was to determine whether the secretory epithelial lining of the fimbria undergoes pregnancy-associated morphological alterations in a concordant manner. Oviducts obtained from ovariectomized, oestrous (day 0) and pregnant (day 1.5, 2, 3, 4, 6 and 16) ewes were analysed quantitatively and qualitatively using light and electron microscopy. The epithelium was low cuboidal in fimbria from ovariectomized sheep, significantly increased in height at day 1.5 of pregnancy, immediately decreased at day 2, and underwent an additional slight reduction at day 6 and day 16 of pregnancy. Ciliated and nonciliated cells were present in the epithelium at all reproductive stages. The proportions of ciliated and nonciliated cells varied during pregnancy and ciliated cells were always the major cell type. Consistent with previous data, the secretory organelles of nonciliated epithelial cells obtained from ovariectomized ewes were poorly developed. Maturation of secretory organelles in nonciliated cells occurred at oestrus and was maintained until days 2-3 of pregnancy; regressive changes were then observed, characterized by atrophy of the Golgi apparatus and rough endoplasmic reticulum, and increases in heterochromatin and pronounced nuclear folds. Large, electron-dense lipid droplets were present throughout the cytoplasm of ciliated and nonciliated epithelial cells, beginning at day 1.5 of pregnancy and increasing at later stages of pregnancy. Apical protrusions and microvilli were observed at the luminal domains of nonciliated cells and were reduced in extent after day 3 of pregnancy. Cells were extruded from the epithelial lining at day 16 of pregnancy. These data show that the epithelial lining of the fimbria oviduct in the sheep undergoes distinct changes in cell height, percentage ciliation and secretory organelle development during the first few weeks of pregnancy.
Authors:
M K Murray
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of reproduction and fertility     Volume:  106     ISSN:  0022-4251     ISO Abbreviation:  J. Reprod. Fertil.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376367     Medline TA:  J Reprod Fertil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  173-83     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cellular Biology, Tufts University, Boston, MA 0211, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Epithelial Cells
Epithelium / physiology,  ultrastructure
Estrus / physiology
Fallopian Tubes / cytology,  physiology*,  ultrastructure
Female
Microscopy, Electron
Organelles / ultrastructure
Ovariectomy
Pregnancy
Pregnancy, Animal / physiology*
Sheep / physiology*
Grant Support
ID/Acronym/Agency:
HD24998/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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