Document Detail

Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging.
MedLine Citation:
PMID:  16442254     Owner:  NLM     Status:  MEDLINE    
Milk synthesis by the mammary gland declines during prolonged lactation despite the continued suckling stimulus and complete removal of mammary secretions. Although this process has been hypothesized to result from cellular aging there has been no reported analysis of aging markers in the lactating mammary gland. The goal of these studies was to relate lactation performance in the mouse during a single prolonged lactation cycle to changes in mammary development and mitochondrial oxidative damage. During an artificially prolonged lactation cycle, the capacity of the dams to support litter growth decreased over time. This decrease was associated with decreased mammary epithelial content. Cell proliferation, along with the percentage of mammary progenitor cells, was high during early lactation, but low during prolonged lactation. Apoptosis increased during prolonged lactation. Oxidative damage to mitochondrial DNA increased during the early postpartum period and remained elevated through the end of the cycle. In contrast oxidative damage to mitochondrial protein was high during early lactation and decreased through mid lactation to increase again with prolonged lactation. The results suggest that a single prolonged lactation cycle may replicate on an accelerated basis some of the changes that occur with a lifetime of aging in organs possessing more stable cell populations.
Darryl L Hadsell; Daniel Torres; Jessy George; Anthony V Capuco; Steven E Ellis; Marta L Fiorotto
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-01-25
Journal Detail:
Title:  Experimental gerontology     Volume:  41     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  271-81     Citation Subset:  IM    
USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston TX, 77030 USA.
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MeSH Terms
Apoptosis / physiology
Cell Aging / physiology*
Cell Division / physiology
DNA, Mitochondrial / physiology
Epithelial Cells / physiology
Lactation / physiology*
Lipid Peroxidation / physiology
Mammary Glands, Animal / growth & development,  physiology*
Mice, Inbred Strains
Mitochondria / physiology*
Mitochondrial Proteins / metabolism
Oxidative Stress / physiology*
Postpartum Period
Stem Cells / physiology
Reg. No./Substance:
0/DNA, Mitochondrial; 0/Mitochondrial Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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