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Changes in salivary flow rates in head and neck cancer after chemoradiotherapy.
MedLine Citation:
PMID:  21358080     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Changes in salivary flow rate were studied in head and neck (H and N) cancer patients who, after receiving moderately accelerated radiotherapy (RT) and concurrent chemotherapy (CT), were free of disease at 1 year. Materials and Methods: Between July 2003 and July 2005, saliva estimation was performed for 36 patients of locally advanced (AJCC stages III and IV) squamous cell carcinoma of the H and N. RT, moderately accelerated (70Gy/35 fx/6 weeks) along with concurrent weekly cisplatin at 35 mg/m 2 (capped at 50 mg) with standard hydration and anti-emetic cover, was planned using conventional planning on telecobalt or 6 MV photons. The saliva flow rate was estimated for 5 min at rest (unstimulated) and after using lemon drops (stimulated) for the next 5 min at baseline (pre-treatment), 3, 6 and 12 months following treatment. Results: The median follow-up of this study was 29 months. Compared with baseline, by 3 months, a significant reduction in unstimulated (0.35 ml/min and 0.10 ml/min) and stimulated (0.97 ml/min and 0.28 ml/min) salivary flow rate was observed, respectively. This continued to decrease further till 6 months (0.06 ml/min and 0.17 ml/min) and, by 12 months, a minimal and non-significant recovery was observed in both unstimulated (0.08 ml/min) and stimulated salivary flow rates (0.22 ml/min), respectively. Conclusions: Salivary flow rates fall to a fourth of the baseline value with the above CT + RT protocol, with minimal recovery at 12 months following completion of treatment.
Authors:
Punita Lal; Ranjeet Bajpai; Rohini Khurana; K J Maria Das; Prabhat Kumar; Anu Tiwari; Neha Gupta; Shaleen Kumar
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cancer research and therapeutics     Volume:  6     ISSN:  1998-4138     ISO Abbreviation:  J Cancer Res Ther     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-03-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101249598     Medline TA:  J Cancer Res Ther     Country:  India    
Other Details:
Languages:  eng     Pagination:  458-62     Citation Subset:  IM    
Affiliation:
Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow - 226 014, India.
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