| Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 18489949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with pulmonary arterial hypertension (PAH) usually show improvements in symptoms, exercise capacity, and hemodynamics after treatment with approved medical therapies. This study sought to determine whether improvement in right-sided cardiac function measured using cardiac magnetic resonance imaging would also be seen and whether these changes would correlate with improvement in exercise capacity. Sixteen patients with PAH underwent evaluation at baseline and after 12 months of treatment with bosentan. After treatment, cardiac index, pulmonary vascular resistance, and 6-minute walk distance improved, and there was a trend toward improvement in right ventricular (RV) stroke volume (70 +/- 27 to 81 +/- 30 ml; p = 0.08), but no change in RV ejection fraction (RVEF) or RV end-diastolic volume. Six-minute walk distance improved by 59 m (p <0.05) in the overall cohort and improved more in patients in whom RVEF increased compared with those with stable or decreased RVEF (+98 vs -37 m, respectively; p = 0.01). Three patients died during follow-up, and these patients had significantly lower RVEF and left ventricular end-diastolic volume indexes than surviving patients. In conclusion, these results suggest that cardiac magnetic resonance imaging may have value in determining response to therapy and prognosis in patients with PAH. |
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Authors:
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Kelly M Chin; Martha Kingman; James A de Lemos; John J Warner; Sharon Reimold; Ron Peshock; Fernando Torres |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-04-18 |
Journal Detail:
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Title: The American journal of cardiology Volume: 101 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-20 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1669-72 Citation Subset: AIM; IM |
Affiliation:
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UT Southwestern Medical Center, Dallas, Texas, USA. kelly.chin@utsouthwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / therapeutic use* Female Follow-Up Studies Heart Ventricles / drug effects, pathology*, physiopathology Humans Hypertension, Pulmonary / complications, drug therapy*, physiopathology Magnetic Resonance Imaging / methods* Male Middle Aged Pulmonary Wedge Pressure / drug effects, physiology Retrospective Studies Stroke Volume / physiology Sulfonamides / therapeutic use* Time Factors Treatment Outcome Ventricular Dysfunction, Right / diagnosis*, etiology, physiopathology Ventricular Function, Right / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Sulfonamides; 147536-97-8/bosentan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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