Document Detail

Changes in right ventricular structure and function assessed using cardiac magnetic resonance imaging in bosentan-treated patients with pulmonary arterial hypertension.
MedLine Citation:
PMID:  18489949     Owner:  NLM     Status:  MEDLINE    
Patients with pulmonary arterial hypertension (PAH) usually show improvements in symptoms, exercise capacity, and hemodynamics after treatment with approved medical therapies. This study sought to determine whether improvement in right-sided cardiac function measured using cardiac magnetic resonance imaging would also be seen and whether these changes would correlate with improvement in exercise capacity. Sixteen patients with PAH underwent evaluation at baseline and after 12 months of treatment with bosentan. After treatment, cardiac index, pulmonary vascular resistance, and 6-minute walk distance improved, and there was a trend toward improvement in right ventricular (RV) stroke volume (70 +/- 27 to 81 +/- 30 ml; p = 0.08), but no change in RV ejection fraction (RVEF) or RV end-diastolic volume. Six-minute walk distance improved by 59 m (p <0.05) in the overall cohort and improved more in patients in whom RVEF increased compared with those with stable or decreased RVEF (+98 vs -37 m, respectively; p = 0.01). Three patients died during follow-up, and these patients had significantly lower RVEF and left ventricular end-diastolic volume indexes than surviving patients. In conclusion, these results suggest that cardiac magnetic resonance imaging may have value in determining response to therapy and prognosis in patients with PAH.
Kelly M Chin; Martha Kingman; James A de Lemos; John J Warner; Sharon Reimold; Ron Peshock; Fernando Torres
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-04-18
Journal Detail:
Title:  The American journal of cardiology     Volume:  101     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-20     Completed Date:  2008-07-15     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1669-72     Citation Subset:  AIM; IM    
UT Southwestern Medical Center, Dallas, Texas, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Follow-Up Studies
Heart Ventricles / drug effects,  pathology*,  physiopathology
Hypertension, Pulmonary / complications,  drug therapy*,  physiopathology
Magnetic Resonance Imaging / methods*
Middle Aged
Pulmonary Wedge Pressure / drug effects,  physiology
Retrospective Studies
Stroke Volume / physiology
Sulfonamides / therapeutic use*
Time Factors
Treatment Outcome
Ventricular Dysfunction, Right / diagnosis*,  etiology,  physiopathology
Ventricular Function, Right / physiology*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Sulfonamides; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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