Document Detail

Changes in renal vascular sensitivity and arterial pressure associated with sodium intake during long-term intrarenal norepinephrine infusion in dogs.
MedLine Citation:
PMID:  396248     Owner:  NLM     Status:  MEDLINE    
Experiments were performed on conscious uninephrectomized dogs to determine the comparative effects of chronic intrarenal and intravenous norephrine (NE) infusion (0.27 microgram/kg/min) on the steady-state values for arterial pressure, plasma renin activity (PRA), and renal function at four levels of sodium intake (5, 40, 120 and 240 mEq/day). Arterial pressure was monitored continuously 24 hr/day with on-line computer techniques. Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and plasma renin activity (PRA) were determined after sodium and water balance was achieved. During intrarenal NE infusion, ERPF and GFR decreased progressively from 15% to 30% and from 24% to 46% respectively, while renal vascular resistance increased progressively from 40% to 140% as sodium intake was increased from 10 to 240 mEq/day. Both ERPF and renal resistance, but not GFR, returned to control levels during intravenous NE infusion at each level of sodium intake and after terminating NE infusion. During intrarenal NE infusion the steady-state value for mean arterial pressure increased from a control of 105 to 118 mm Hg when the sodium intake was 10 mEq/day. Pressure then increased progressively from 118 to 135 mm Hg as the sodium intake was elevated from 10 to 240 mEq/day. Increases in arterial pressure associated with intravenous NE infusion were significantly smaller at each sodium level than those achieved with intrarenal NE infusion. At each level of sodium intake, PRA was elevated during intrarenal NE infusion and returned to control after NE infusion. Intravenous NE infusion did not increase PRA above control levels. The data are compatible with the concept that enhanced renal adrenergic activity could initiate and sustain hypertension chronically by basic alterations in renal function.
A W Cowley; T E Lohmeier
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  1     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1979 Nov-Dec
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  549-58     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Glomerular Filtration Rate / drug effects
Infusions, Intra-Arterial
Infusions, Parenteral
Kidney / physiology*
Norepinephrine / administration & dosage,  pharmacology*,  physiology
Postmortem Changes
Renal Artery
Renal Veins
Renin / blood
Sodium / administration & dosage,  metabolism*,  pharmacology,  physiology*
Vascular Resistance / drug effects
Water-Electrolyte Balance / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 7440-23-5/Sodium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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