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Changes in renal function in early pregnancy in women with one kidney.
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MedLine Citation:
PMID:  366926     Owner:  NLM     Status:  MEDLINE    
In healthy women the 24-hour endogenous creatinine clearance is elevated by some 50 percent within 6 weeks of conception and an analogous increase of the 24-hour glucose excretion occurs. 24-hour glucose excretion later reverts to normal, reflecting a delayed onset of increased tubular reabsorption.Following unilateral nephrectomy there are marked increases in RPF and GFR in the contralateral kidney. Single hypertrophied kidneys apparently can adapt still further as in normal pregnancy. We have studied 5 women, in satisfactory general health prior to the pregnancy, each with only one kidney, before conception and during early pregnancy. Three had had unilateral nephrectomy for renal trauma 6-9 years earlier. two had received renal allografts 3 years earlier. In all cases the endogenous creatinine clearance began to rise in the second half of the menstrual cycle and when pregnancy supervened it rose rapidly to a peak value of 30-40 percent above the midcycle level within 7-10 weeks of the last menstrual period. That early peak was not always sustained and GFR subsequently fell to a level of 25-30 percent above the midcycle level. These changes in renal function were slower and smaller than in healthy women with 2 kidneys but were compatible with a successful outcome of pregnancy in these five cases.
J M Davison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  51     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
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MeSH Terms
Blood Glucose
Creatinine / urine
Glomerular Filtration Rate
Kidney / physiology*
Kidney Transplantation
Transplantation, Homologous
Urea / blood
Reg. No./Substance:
0/Blood Glucose; 57-13-6/Urea; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
ISSN: 0044-0086
ISSN: 1551-4056
Article Information
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Print publication date: Season: May?Jun Year: 1978
Volume: 51 Issue: 3
First Page: 347 Last Page: 349
ID: 2595754
PubMed Id: 366926
PubMed Id: 366926

Changes in Renal Function in Early Pregnancy in Women with One Kidney
J.M. Davison

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Series: Long-Term Responses to Loss of Renal Mass: Pathophysiological Aspects.

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