| Changes in renal blood flow reserve after angioplasty of renal artery stenosis in hypertensive patients. | |
| | |
MedLine Citation:
|
PMID: 14675056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Intra-arterial Doppler is a recent technique which allows assessment of distal vascular disease using measurements of intrarenal blood flow velocities. The purpose of this study was to evaluate intrarenal hemodynamics and renal blood flow reserve before and after percutaneous transluminal angioplasty (PTA) in hypertensive patients with unilateral atherosclerotic renal artery stenosis using intra-arterial Doppler. METHODS: Intra-arterial Doppler was performed during arteriography in 19 hypertensive patients (12 men; mean age, 64 +/- 8 years) in "normal" and in "stenotic" kidneys at baseline, on isosorbide dinitrate, and after selective intra-renal papaverine injection, before, and after PTA. Doppler parameters analyzed were average peak velocity, maximum peak velocity, end diastolic velocity, and renal blood flow (RBF). Changes in Doppler parameters after papaverine injection were also analyzed. RESULTS: The major results were (1) the significant reduction in RBF distal to the stenosis, (2) the lack of arteriolar reactivity in response to papaverine distal to the stenosis, (3) the immediate recovery of arteriolar reactivity after PTA, associated with restoration of RBF in the revascularized kidneys, and (4) no change in arteriolar reactivity in response to papaverine in the "normal" kidneys following PTA. CONCLUSION: Ours results highlighted the benefit of endovascular Doppler to evaluate (1) RBF reserve, and (2) the repercussion of the stenosis on the distal vascularization. |
| | |
Authors:
|
Claire Mounier-Vehier; Benjamin Cocheteux; Stephan Haulon; Patrick Devos; Christophe Lions; Corinne Gautier; Alain Carre; Jean-Paul Beregi |
Related Documents
:
|
3581686 - Haemodynamic consequences of experimental papillary necrosis in the rat. 11506986 - N-acetyl-l-cysteine improves renal medullary hypoperfusion in acute renal failure. 2505426 - Hepatic blood flow and drug metabolism in glycerol-rechallenged rats. 7532326 - Serotonergic measures in cyclosporine a treated rats. 15556666 - Magnetically induced electric fields and currents in the circulatory system. 16021296 - Blood transfusion and iatrogenic risks in mexico city. anti-trypanosoma cruzi seropreva... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Kidney international Volume: 65 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2003-12-16 Completed Date: 2004-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 245-50 Citation Subset: IM |
Affiliation:
|
Service de Médecine Interne et HTA, Hôpital Cardiologique, CHRU, Lille Cédex, France. cmouniervehier@chru-lille.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angioplasty, Balloon* Female Humans Hypertension, Renal / physiopathology, therapy*, ultrasonography* Male Middle Aged Papaverine / administration & dosage Renal Artery Obstruction / physiopathology, therapy*, ultrasonography* Renal Circulation Ultrasonography, Doppler Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiotensin II receptor blockade prevents acute renal sodium retention induced by low levels of orth...
Next Document: Delay of dialysis in end-stage renal failure: prospective study on percutaneous renal artery interve...