| Changes in regional cerebral blood flow following mood challenge in drug-free, remitted patients with unipolar depression. | |
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MedLine Citation:
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PMID: 17133439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies of mood provocation in remitted patients with depression have enabled the description of specific brain changes relevant to depression relapse vulnerability. Because patients in these studies were also receiving maintenance pharmacotherapy, the ability to subtract out the drug effect from the changes observed is reduced. Our study addresses this concern. Changes in regional cerebral blood flow (rCBF) among 11 medication-free, remitted patients with unipolar depression relative to baseline state were assessed with [(15)O]H(2)O positron emission tomography (PET) following provocation of sadness. Participants showed decreased activation in prefrontal cortex similar to those reported for remitted, medicated patients undergoing mood challenge, as well as for acutely depressed patients who were medication free. Previously reported mediofrontal changes in remitted patients are unlikely to be a consequence of maintenance medication and more likely are evidence of relapse vulnerability. |
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Authors:
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Michael C Gemar; Zindel V Segal; Helen S Mayberg; Kimberley Goldapple; Colleen Carney |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Depression and anxiety Volume: 24 ISSN: 1091-4269 ISO Abbreviation: Depress Anxiety Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-03-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708816 Medline TA: Depress Anxiety Country: United States |
Other Details:
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Languages: eng Pagination: 597-601 Citation Subset: IM |
Affiliation:
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Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / blood supply*, physiopathology*, radionuclide imaging Cerebrovascular Circulation / physiology Depressive Disorder / physiopathology*, psychology* Female Humans Male Positron-Emission Tomography Prefrontal Cortex / blood supply, physiopathology, radionuclide imaging Questionnaires |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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