| Changes in regional cerebral blood flow after electroconvulsive therapy for depression. | |
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MedLine Citation:
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PMID: 11281509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifteen patients with major depression and normal results of magnetic resonance imaging or computed tomographic studies were treated by electroconvulsive therapy (ECT). The regional cerebral blood flow (rCBF) of these patients was imaged using Tc-99m hexamethylpropylene amineoxime single-photon emission computed tomography before and after treatment, and their images were compared with a population of 11 healthy volunteers. Before ECT treatment, the patients had hypoperfusion of the frontal region compared with the controls, and they had multiple areas of altered perfusion throughout the brain. Five of the patients had an excellent clinical response to ECT; these patients also showed changes toward normal in rCBF. The remaining patients had minimal to moderate clinical response and showed no significant change in rCBF. These results indicate that improvement in clinical status as a result of ECT is correlated with a change toward normal in rCBF. |
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Authors:
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T J Milo; G E Kaufman; W E Barnes; L M Konopka; J W Crayton; J G Ringelstein; P H Shirazi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of ECT Volume: 17 ISSN: 1095-0680 ISO Abbreviation: J ECT Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-04-02 Completed Date: 2001-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9808943 Medline TA: J ECT Country: United States |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Service and Psychiatry Service, Hines Veterans Administration Hospital, Illinois 60141-5115, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cerebral Cortex / blood supply* Depressive Disorder / therapy* Electroconvulsive Therapy* Female Humans Male Middle Aged Radiopharmaceuticals / diagnostic use Regional Blood Flow Technetium Tc 99m Exametazime / diagnostic use Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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