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Changes in the redox status and inflammatory response in handball players during one-year of competition and training.
MedLine Citation:
PMID:  23464526     Owner:  NLM     Status:  Publisher    
Abstract The present research was designed to evaluate the adaptive responses to oxidative stress and inflammation in handball players subjected to well-controlled training intervals over one-year of competition. Seven blood samples were collected over the season of the study, approximately one a month. Plasma lipid peroxidation, nitrite, cytokines (IL-1β, IL-6, INFγ and TNFα), and the glutathione cycle in erythrocytes, were measured. Exercise intensity, measured with the Borg's scale, increased significantly up to the middle of the competition season, coinciding with maximal creatine kinase and lactate dehydrogenase values, and then decreased at the end of the study. The inflammatory markers including nitrite, IL-1β, IL-6, and, to a lesser extent INFγ, increased early in the training season, and remained elevated until the end of the study. TNFα, however, remained low during the season. The oxidative stress response included a transient increase of the glutathione disulphide/glutathione ratio and glutathione reductase activity at the beginning of the study, returning to basal values somewhat later. Glutathione peroxidase also increased at the end of the training season, and lipid peroxidation levels remained low during the athletic season. These results suggest that well-trained athletes were best adapted to the oxidative response, although the beneficial effects of some of the inflammatory cytokines on skeletal muscle myogenesis and repair cannot be ruled out.
Melquiades Concepcion-Huertas; Luis Javier Chirosa; Tomas De Haro; Ignacio Javier Chirosa; Vicente Romero; David Aguilar-Martinez; Roberto Carlos Leonardo-Mendonça; Carolina Doerrier; Germaine Escames; Dario Acuña-Castroviejo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-7
Journal Detail:
Title:  Journal of sports sciences     Volume:  -     ISSN:  1466-447X     ISO Abbreviation:  J Sports Sci     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Department of Physiology , University of Granada , Armilla , Spain.
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