Document Detail

Changes in the ratio of branched-chain to aromatic amino acids affect the secretion of albumin in cultured rat hepatocytes.
MedLine Citation:
PMID:  7575508     Owner:  NLM     Status:  MEDLINE    
The effect of branched-chain amino acids (BCAAs) on the synthesis and secretion of albumin was studied in the primary cultures of rat hepatocytes. The changes in the normal BCAAs/aromatic amino acids (AAAs) ratio reduced the secretion of albumin without altering its mRNA levels. Protein-labeling and pulse-chase experiments showed that a low BCAAs/AAAs ratio reduced the biosynthesis, whereas a high ratio accelerated intracellular decay of albumin. These results suggest that normalization of the BCAAs/AAAs ratio improves albumin synthesis while the excess ratio may induce the degradation of albumin in the cells.
M Okuno; H Moriwaki; M Kato; Y Muto; S Kojima
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  214     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-11-02     Completed Date:  1995-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1045-50     Citation Subset:  IM    
First Department of Internal Medicine, Gifu University School of Medicine, Japan.
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MeSH Terms
Amino Acids, Branched-Chain / pharmacology*
Cells, Cultured
Gene Expression
Isoleucine / pharmacology
Leucine / pharmacology
Liver / drug effects,  metabolism*
Phenylalanine / pharmacology*
RNA, Messenger / analysis,  biosynthesis
Rats, Wistar
Serum Albumin / biosynthesis*
Tyrosine / pharmacology*
Valine / pharmacology
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/RNA, Messenger; 0/Serum Albumin; 55520-40-6/Tyrosine; 61-90-5/Leucine; 63-91-2/Phenylalanine; 7004-03-7/Valine; 73-32-5/Isoleucine

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