Document Detail


Changes in rat olfactory detection performance induced by orexin and leptin mimicking fasting and satiation.
MedLine Citation:
PMID:  17624453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous peripheral and hypothalamic peptides control food intake. Among these signals are orexin, an orexigenic molecule released into the olfactory bulb by centrifugal hypothalamic fibres and leptin, an anorexigenic molecule that is released peripherally and can pass through the blood-brain barrier. In the present study, we injected either orexin or leptin, intracerebroventricularly, and their effect on olfactory performance was evaluated in two groups of rats, using a behavioral paradigm based on conditioned olfactory aversion. Rats were made aversive to water odorized with isoamyl acetate (ISO) at 10(-5) (1microl in 100ml of water). One group was injected with orexin versus saline and the other with leptin versus saline. They were then presented with different concentrations (lower than 10(-5)) of ISO-odorized water to compare their ability to avoid the ISO-drink. Orexin decreased ISO-drink consumption, showing increased avoidance of the ISO concentrations tested which ranged from 10(-9) to 10(-7). Conversely, the administration of leptin resulted in a dose dependant increase in the odorized-drink consumption for ISO 10(-10). Orexin therefore increases and leptin decreases olfactory sensitivity. Orexin and leptin modulate the olfactory performance in a similar way as do physiological induced fasting and satiation and appear to be important factors in the interdependency of olfaction and food intake.
Authors:
A K Julliard; M A Chaput; A Apelbaum; P Aimé; M Mahfouz; P Duchamp-Viret
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-02
Journal Detail:
Title:  Behavioural brain research     Volume:  183     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-12-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Affiliation:
Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, CNRS, UMR 5020, Université de Lyon, Lyon 1, 50 Avenue Tony Garnier, 69366 Lyon Cedex 07, France.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Avoidance Learning / drug effects,  physiology
Behavior, Animal / drug effects
Dose-Response Relationship, Drug
Fasting*
Feeding Behavior / drug effects
Injections, Intraventricular / methods
Intracellular Signaling Peptides and Proteins / administration & dosage*
Leptin / administration & dosage*
Male
Neuropeptides / administration & dosage*
Neurotransmitter Agents / administration & dosage*
Rats
Rats, Wistar
Satiation / drug effects*
Signal Detection, Psychological / drug effects*,  physiology
Smell / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Neuropeptides; 0/Neurotransmitter Agents; 0/orexins

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