Document Detail


Changes in pupil dynamics at high altitude--an observational study using a handheld pupillometer.
MedLine Citation:
PMID:  19115917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gross pupil dynamics are used as an indirect measure of brain function. Changes in hypoxia and intracranial pressure are thought to alter pupil responses to light. This study assessed a portable handheld pupil measuring device (pupillometer) in the field investigating the changes in pupil size, speed of reaction, and rate of constriction/dilatation with hypoxia induced by changes in altitude. A correlation between pupil dynamics and acute mountain sickness was sought. Seventeen volunteers were studied following acute exposure to 3450 m and then during a trek to 4770 m in Ladakh, India. The pupillometer was used to record maximum and minimum pupil diameter in response to a standard light source with calculation of latency, constriction and dilatation velocities. Acute mountain sickness (AMS) was recorded using Lake Louise self completed questionnaires both in the morning and afternoon on each day. Acute altitude exposure resulted in a significant reduction of percentage change in pupil size (36.5% to 24.1% p=<0.001), significant delay in pupillary contraction (latency; 0.208 to 0.223 seconds p=0.015) and a significant slowing of the rate of contraction (constriction velocity; -2.77 mm/s to -1.75 mm/s p=0.012). These changes reverted to normal during a period of acclimatization. A significant diurnal variation in pupil size was also observed. There was no significant difference between subjects with and without AMS. The handheld pupillometer is a suitable robust tool for monitoring changes in pupil dynamics in the field. With acute exposure to hypobaric hypoxia associated with an ascent to a moderate altitude, there is a general slowing of pupil function which reverts to normal within a few days of acclimatization. There appears to be a marked diurnal variation in pupil size. The measurements clearly demonstrated an effect of hypoxia on cerebral function, but these changes did not relate to moderate AMS.
Authors:
Mark H Wilson; Mark Edsell; Chris Imray; Alex Wright;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  9     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-25     Citation Subset:  IM; S    
Affiliation:
London Helicopter Emergency Medical Service, The Helipad, The Royal London Hospital, Whitechapel, London, UK. mark@rcsed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology*
Acute Disease
Adult
Aged
Altitude*
Altitude Sickness / physiopathology
Analysis of Variance
Diagnostic Techniques, Ophthalmological / instrumentation*
Environmental Monitoring / methods*
Female
Humans
India
Male
Middle Aged
Prospective Studies
Pupil / physiology*
Reference Values
Reflex, Pupillary / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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