Document Detail


Changes in pulmonary mechanics following caffeine administration in infants with bronchopulmonary dysplasia.
MedLine Citation:
PMID:  2704583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of caffeine upon pulmonary mechanics were measured in 16 infants with bronchopulmonary dysplasia (BPD). Pulmonary function tests were performed immediately prior to and 1 hour following a dose of 10 mg/kg of caffeine. A 37% increase in minute ventilation (mean +/- SEM; 436.6 +/- 26.3 to 580.8 +/- 30.7 ml/min/kg) was seen with caffeine administration (P less than 0.001), primarily from a 42% increase in tidal volume (6.2 +/- 0.4 to 8.5 +/- 0.4 ml/kg) (P less than 0.001). Total lung resistance decreased by 20% (134.6 + 24.2 to 105.3 +/- 20.1 cmH2O/L/sec) (P = 0.01), and total pulmonary compliance improved by 47% (0.642 +/- 0.104 to 0.908 +/- 0.190 ml/cmH2O/kg) (P less than 0.01). In five matched control infants with BPD, no effects of placebo upon pulmonary mechanics were detected. Since caffeine has a wide therapeutic index with few side effects, it may be an effective adjunct in the treatment of infants with BPD.
Authors:
J M Davis; V K Bhutani; J L Stefano; W W Fox; A R Spitzer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  6     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-05-15     Completed Date:  1989-05-15     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-52     Citation Subset:  IM    
Affiliation:
Department of Pediatrics (Neonatology), Strong Memorial Hospital, Rochester, NY 14642.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / drug effects*
Bronchopulmonary Dysplasia / drug therapy,  physiopathology*
Caffeine / adverse effects,  pharmacology*,  therapeutic use
Humans
Infant
Infant, Newborn
Lung Compliance / drug effects*
Chemical
Reg. No./Substance:
58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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