| Changes in pulmonary hemodynamics predict benefits in exercise capacity after ACE inhibition in patients with mild to moderate congestive heart failure. | |
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MedLine Citation:
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PMID: 8370193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several causes may affect the efficacy of angiotensin-converting enzyme (ACE) inhibitors in congestive heart failure (CHF). The present study was undertaken to identify what factors might predict benefits in exercise capacity after ACE inhibition in 22 patients with mild to moderate CHF. All patients underwent hemodynamic evaluation before and following an oral dose of quinapril (20 mg). They were then treated daily with 20 mg of quinapril and underwent exercise stress test off-drugs 1 day and 6 months later. Patients were grouped according to their relative changes in vascular resistances after quinapril: Group A (n = 15) showed a greater decrease in pulmonary vascular resistance (PVR) than in systemic vascular resistance (SVR) (% delta PVR/% delta SVR > 1). The opposite occurred in Group B (n = 7). Comparison of pretreatment baseline features revealed that the two groups had similar biochemical and hormonal variables, cardiac index, and SVR. Conversely, Group A patients had higher (p < 0.05) pulmonary artery pressure and PVR compared with Group B patients. Following quinapril, Group A patients showed a greater (p < 0.05) increase in cardiac index than Group B patients, despite a similar reduction in SVR. Accordingly, 1-day drug treatment significantly (p < 0.001) increased exercise duration in Group A (+29%), but not in Group B patients (+7%). Benefits in exercise capacity were still significant (p < 0.001) 6 months later.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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F Pelliccia; A Borghi; A Ruggeri; C Cianfrocca; G L Morgagni; R Bugiardini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 16 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1993-10-14 Completed Date: 1993-10-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 607-12 Citation Subset: IM |
Affiliation:
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Istituto di Patologia Medica, University of Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Angiotensin-Converting Enzyme Inhibitors / administration & dosage, therapeutic use* Atrial Function, Right / drug effects Blood Pressure / drug effects Cardiac Output / drug effects Exercise Test Exercise Tolerance / physiology* Female Heart Failure / drug therapy*, physiopathology* Hemodynamics / drug effects Humans Isoquinolines / administration & dosage, therapeutic use* Lung / physiopathology* Male Middle Aged Pulmonary Artery / drug effects, physiopathology Pulmonary Wedge Pressure / drug effects Stroke Volume / drug effects Tetrahydroisoquinolines* Time Factors Vascular Resistance / drug effects Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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