| Changes in proton T1 in dog brains due to the administration of haloperidol. | |
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MedLine Citation:
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PMID: 3431357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in proton T1 in dog brains due to the administration of haloperidol were determined by the intravenous administration of a single dose of 20 mg of haloperidol to mongrel dogs. The MRI used was the Aberdeen type with the static magnetic field of 0.1 T. A coil made exclusively for these animals (bore diameter 120 mm) was used. There was a significant increase in the T1 value in the striate body 30 minutes and more (within two hours) after the administration of haloperidol. Subtraction images were also obtained by subtracting the image of the pre-treatment (control) T1 values from the image of the post-treatment values (2 hours after the injection). The subtraction images also revealed increases in the T1 values of the striate body. |
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Authors:
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T Fujimoto; T Nakano; M Fujii; A Okada; K Harada; Y Yokoyama; T Uchida; T Tsuji; A Igata; T Asakura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 5 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 1987 |
Date Detail:
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Created Date: 1988-02-26 Completed Date: 1988-02-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 469-74 Citation Subset: IM |
Affiliation:
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South Japan Health Science Center, Fujimoto Hospital, Miyazaki Prefecture. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / anatomy & histology, drug effects* Corpus Striatum / anatomy & histology, drug effects Dogs Haloperidol / pharmacology* Magnetic Resonance Imaging* Schizophrenia / diagnosis Thalamus / anatomy & histology, drug effects |
| Chemical | |
Reg. No./Substance:
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52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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