Document Detail


Changes in progesterone metabolites in the hippocampus can modulate open field and forced swim test behavior of proestrous rats.
MedLine Citation:
PMID:  11971664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of these experiments was to test the hypothesis that attenuating the endogenous increase of the 5alpha-reduced progesterone metabolite 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP) in the hippocampus will alter anxiety and depression behavior of proestrous rats. In Experiment 1, anxiety (open field) and depression (forced swim test) behavior was compared of rats that should have high (proestrous) and low (diestrous and male rats) endogenous hippocampal 3alpha,5alpha-THP. Proestrous rats exhibited more anxiolytic-like (increased central entries in the open field) and anti-depressant-like (less immobility in the forced swim test) behavior than diestrous or male rats. In Experiments 2 and 3, respectively, systemic and intrahippocampal finasteride, a 5alpha-reductase inhibitor which attenuates progesterone's metabolism to 3alpha,5alpha-THP, versus vehicle administration to proestrous rats was compared for effects on open field and forced swim test behavior. Systemic or intrahippocampal finasteride decreased central entries in the open field and increased immobility in the forced swim tests compared to vehicle administration. In Experiment 4, the effects of systemic and intrahippocampal finasteride vs vehicle administration on hippocampal 3alpha,5alpha-THP of proestrous rats was examined. Finasteride, SC or intrahippocampally, reduced 3alpha,5alpha-THP in the hippocampus compared to vehicle administration. Together these data suggest that variations in 3alpha,5alpha-THP levels in the hippocampus may mitigate proestrous changes in anxiety and depressive behavior of cycling rats.
Authors:
Cheryl A Frye; Alicia A Walf
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Hormones and behavior     Volume:  41     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-04-24     Completed Date:  2002-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  306-15     Citation Subset:  IM    
Copyright Information:
(c) 2002 Elsevier Science (USA).
Affiliation:
Department of Psychology, The University at Albany-SUNY, 1400 Washington Avenue, New York, 12222, USA. cafrye@cnsunix.albany.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / metabolism
Depression / metabolism
Enzyme Inhibitors / pharmacology
Exploratory Behavior / physiology*
Female
Finasteride / pharmacology
Hippocampus / drug effects,  metabolism*
Male
Posture
Pregnanolone / metabolism
Proestrus / metabolism*
Progesterone / metabolism*
Progestins / metabolism
Rats
Rats, Long-Evans
Sex Characteristics
Sexual Behavior, Animal / physiology
Swimming / physiology
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Progestins; 128-20-1/Pregnanolone; 57-83-0/Progesterone; 98319-26-7/Finasteride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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