| Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene. | |
| | |
MedLine Citation:
|
PMID: 201366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The concentrations of putrescine, spermidine, and spermine in liver of rats fed on 4-dimethylaminoazobenzene and in the resultant hepatomas were found to be significantly higher than were those observed in normal liver from rats of the same strain, sex, and age. These modifications were due to the carcinogen and not to the special low-riboflavin diet used to obtain the carcinogenic effect of 4-dimethylaminoazobenzene. The first change observed during liver carcinogenesis was the early increase in the putrescine level, followed by an increase of spermidine and spermine, which reached maximum levels in growing hepatomas. A significant increase of urinary polyamines was also observed in tumor-bearing rats. Experiments on leucine incorporation into proteins of tissue slices, which were obtained from the same tissues on which polyamine determinations were carried out, showed that in rat liver carcinogenesis the rate of protein synthesis was well correlated with the polyamine levels. These results suggest that polyamines may play a role in the process of carcinogenesis and in tumor protein synthesis in vivo. |
| | |
Authors:
|
A Perin; A Sessa |
Related Documents
:
|
8396716 - Rat cyp1a1 negative regulatory element: biological activity and interaction with a prot... 12127056 - Ultrasonographic evidence of phenotypic instability during hepatocarcinogenesis in n-ni... 163316 - A new common marker for premalignant and malignant hepatocytes induced in the rat by ch... 186116 - Oxidative phosphorylation properties of mitochondria isolated from transplanted hepatoma. 861316 - Site of horseadish peroxidase transport by the small intestine of the neonatal rat. 22177986 - The effect of sodium selenite on liver growth and thioredoxin reductase expression in r... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Cancer research Volume: 38 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1978 Jan |
Date Detail:
|
Created Date: 1978-02-18 Completed Date: 1978-02-18 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Carcinoma, Hepatocellular / chemically induced, metabolism* Liver Neoplasms / chemically induced, metabolism* Male Neoplasm Proteins / biosynthesis* Neoplasms, Experimental / metabolism Polyamines / metabolism*, physiology, urine Precancerous Conditions / chemically induced, metabolism* Putrescine / metabolism Rats Spermidine / metabolism Spermine / metabolism p-Dimethylaminoazobenzene* |
| Chemical | |
Reg. No./Substance:
|
0/Neoplasm Proteins; 0/Polyamines; 110-60-1/Putrescine; 124-20-9/Spermidine; 60-11-7/p-Dimethylaminoazobenzene; 71-44-3/Spermine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Wilms' tumor in New York State: epidemiology and survivorship.
Next Document: Initial reaction of 3-ethyoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) copper(II) with Ehrlich as...