Document Detail

Changes in plasma and urinary amino acid levels during diabetic ketoacidosis in children.
MedLine Citation:
PMID:  1908767     Owner:  NLM     Status:  MEDLINE    
Plasma and urinary concentrations of different amino acids were investigated during diabetic ketoacidosis (DKA) and 12, 24, 72 hours after initiation of therapy. In DKA, plasma concentration of glutamic acid, aspartic acid, valine, leucine and isoleucine significantly increased while that of asparagine and glutamine decreased compared to levels in well-controlled diabetic patients. The urinary excretion of branched-chain amino acids, histidine, serine and threonine was elevated while those of glutamic acid, glutamine, glycine and taurine were reduced. Among the different amino acids, histidine excretion had the highest variability. A strong correlation was found between the urinary excretion of several amino acids and that of the beta-2-microglobulin characterizing tubular dysfunction. Changes in the excretion of different amino acids reflect the altered metabolic state and renal function due to DKA.
A Szabó; E Kenesei; A Körner; M Miltényi; L Szücs; I Nagy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  12     ISSN:  0168-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-10-02     Completed Date:  1991-10-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
1st Department of Pediatrics, Semmelweis University Medical School, Budapest, Hungary.
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MeSH Terms
Amino Acids / blood*,  urine
Blood Glucose / metabolism
Diabetes Mellitus, Type 1 / blood*,  urine
Diabetic Ketoacidosis / blood*,  therapy,  urine
Reference Values
Regression Analysis
Time Factors
beta 2-Microglobulin / urine
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/beta 2-Microglobulin

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