| Changes in plasma and urinary amino acid levels during diabetic ketoacidosis in children. | |
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MedLine Citation:
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PMID: 1908767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma and urinary concentrations of different amino acids were investigated during diabetic ketoacidosis (DKA) and 12, 24, 72 hours after initiation of therapy. In DKA, plasma concentration of glutamic acid, aspartic acid, valine, leucine and isoleucine significantly increased while that of asparagine and glutamine decreased compared to levels in well-controlled diabetic patients. The urinary excretion of branched-chain amino acids, histidine, serine and threonine was elevated while those of glutamic acid, glutamine, glycine and taurine were reduced. Among the different amino acids, histidine excretion had the highest variability. A strong correlation was found between the urinary excretion of several amino acids and that of the beta-2-microglobulin characterizing tubular dysfunction. Changes in the excretion of different amino acids reflect the altered metabolic state and renal function due to DKA. |
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Authors:
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A Szabó; E Kenesei; A Körner; M Miltényi; L Szücs; I Nagy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 12 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 1991 May |
Date Detail:
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Created Date: 1991-10-02 Completed Date: 1991-10-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 91-7 Citation Subset: IM |
Affiliation:
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1st Department of Pediatrics, Semmelweis University Medical School, Budapest, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Amino Acids / blood*, urine Blood Glucose / metabolism Child Diabetes Mellitus, Type 1 / blood*, urine Diabetic Ketoacidosis / blood*, therapy, urine Female Humans Male Reference Values Regression Analysis Time Factors beta 2-Microglobulin / urine |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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