Document Detail


Changes in plasma triacylglycerol concentrations after sequential lunch and dinner in healthy subjects.
MedLine Citation:
PMID:  15803116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The present study examines the kinetic of plasma triacylglycerol (TAG) after sequential ingestion of lunch and dinner as well as the contribution of dietary fat ingested at lunch to subsequent post-dinner TAG composition. METHOD: Six healthy subjects were included. After standardized breakfast (7: 30AM), 2 mixed meals with fat loads composed of 44 g olive oil (rich in oleic acid) at lunch (12PM) and 44 g sunflower oil (rich in linoleic acid) at dinner (7PM) were ingested. [1-13C] palmitate was added in lunch only. Plasma TAG and chylomicron-TAG (CMTAG) levels were measured sequentially after meals. [1-13C] palmitate enrichment and concentrations of oleic acid and linoleic acid were measured in all lipid fractions. RESULT: Post-dinner plasma TAG peak was delayed as compared to lunch (3 hours vs 1 hour, p=0.002) whereas the magnitude of the postprandial peaks was not significantly different between lunch and dinner (2.4+/-0.3 vs 2.0+/-0.4 mmol/L, p=0.85). [1-13C] palmitate enrichment was maximal 5 hours after lunch in all lipid fractions and decreased slowly thereafter. After dinner ingestion, the rate of decline of [1-13C] palmitate enrichment plateaued during the first 60 minutes. Oleic acid increased slightly and immediately after dinner and remained the predominant fatty acid in all lipid fractions during the first hour after dinner. A delayed peak of plasma and CM-TAG was observed after dinner as compared to lunch without difference in the magnitude of peaks. CONCLUSION: The contribution of dietary fat ingested at lunch to post-dinner lipemia is confirmed despite the relatively long lasting interval between the 2 meals (7 h) and the absence of any early peak of plasma TAG after dinner.
Authors:
F Maillot; M A Garrigue; M Pinault; M Objois; V Théret; F Lamisse; C Hoinard; J M Antoine; D Lairon; C Couet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes & metabolism     Volume:  31     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-01     Completed Date:  2005-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  69-77     Citation Subset:  IM    
Affiliation:
Laboratoire de Nutrition, INSERM 0211, Faculté de Médecine de Tours, France. maillot@med.univ-tours.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Circadian Rhythm
Dietary Fats*
Humans
Male
Plant Oils
Postprandial Period*
Reference Values
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Plant Oils; 0/Triglycerides; 8001-21-6/sunflower seed oil; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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