Document Detail


Changes in plasma thyroid hormone concentrations in chronically food-restricted female rats and their offspring during suckling.
MedLine Citation:
PMID:  1542002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the joint effects of lactation and dietary restriction on thyroid function, we studied chronically food-restricted rat dams at conception and dams and their pups during the nursing period compared with controls that had free access to food. As expected, both dietary restriction [plasma thyroxine and 3,3',5-triiodothyronine (T3) values were lower and reverse T3 (rT3) values were higher in food-restricted than in control rats] and stage of lactation (T3 values decreased in both groups) had independent effects on maternal thyroid function. There also were interactive effects: rT3 values decreased during lactation among the food-restricted dams but remained constant among controls. Maternal dietary restriction also did not have a consistent effect on pup thyroid function during the nursing period: in offspring of food-restricted compared with control dams, plasma thyroxine values were lower only at d 14, T3 values were lower at d 7-21, and rT3 values were higher from birth to d 14. These data demonstrate that dietary restriction and lactation have synergistic negative effects on thyroid status in lactating rats and their pups and that thyroid hormone ontogeny is retarded in the offspring of food-restricted rats. These hormonal effects may contribute to the impaired milk production of food-restricted rats and to altered growth characteristics of their offspring.
Authors:
L V Oberkotter; K M Rasmussen
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  122     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-08     Completed Date:  1992-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-41     Citation Subset:  IM    
Affiliation:
Division of Cell and Molecular Biology, Florida Institute of Technology, Melbourne 32901.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Food Deprivation / physiology*
Lactation / physiology*
Pregnancy
Radioimmunoassay
Random Allocation
Rats
Rats, Inbred Strains
Thyroid Gland / physiology*
Thyroid Hormones / blood*
Thyroxine / blood
Triiodothyronine / blood
Triiodothyronine, Reverse / blood
Grant Support
ID/Acronym/Agency:
HD 14953/HD/NICHD NIH HHS; HD 21227/HD/NICHD NIH HHS; HD 27068/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Thyroid Hormones; 5817-39-0/Triiodothyronine, Reverse; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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