Document Detail

Changes in the plasma protease systems during open-heart surgery with dextran vs. Ringer acetate as priming solution.
MedLine Citation:
PMID:  2482539     Owner:  NLM     Status:  MEDLINE    
Two different priming solutions for cardiopulmonary bypass (CPB) were studied in regard to possible influence on the plasma protease systems. The study was performed on 20 patients undergoing elective coronary artery bypass grafting. In ten cases the priming solution contained 1,000 ml dextran (MW 70,000) and in ten it consisted only of Ringer's acetate solution. The same level of haemodilution was established during CPB in the two groups. Clinical variables and laboratory data were monitored. Spontaneous kallikrein activity, plasma prekallikrein, functional kallikrein inhibition capacity, spontaneous plasmin activity, plasminogen, functional antiplasmin activity, prothrombin and antithrombin-III were measured, using chromogenic peptide substrate assays before and during CPB as well as in the postoperative period. The antiplasmin activity decreased more in the dextran than in the Ringer group following cardiopulmonary bypass but the difference was without clinical significance. No statistically significant intergroup difference was found in the other measured variables of the kallikrein-kinin, fibrinolytic and coagulation systems.
U E Kongsgaard; N Smith-Erichsen; O Geiran; L Bjørnskau
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of thoracic and cardiovascular surgery     Volume:  23     ISSN:  0036-5580     ISO Abbreviation:  Scand J Thorac Cardiovasc Surg     Publication Date:  1989  
Date Detail:
Created Date:  1990-03-05     Completed Date:  1990-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121343     Medline TA:  Scand J Thorac Cardiovasc Surg     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  253-8     Citation Subset:  IM    
Department of Anaesthesiology, Rikshospitalet, Oslo, Norway.
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MeSH Terms
Cardiopulmonary Bypass / methods*
Dextrans / pharmacology*
Fibrinolysis / drug effects*
Isotonic Solutions / pharmacology*
Kallikreins / blood*
Middle Aged
Peptide Hydrolases / blood*
Reg. No./Substance:
0/Isotonic Solutions; 8026-10-6/Ringer's solution; 9004-54-0/Dextrans; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.-/Kallikreins

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