Document Detail


Changes in the plasma kinin system in patients with myocardial infarction.
MedLine Citation:
PMID:  1204357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of kininogen, prekallikrein and kininase activity in the plasma of 54 patients with myocardial infarction were studied. It was demonstrated that in acute myocardial infarction (during the first two days after its onset) the level of kininogen and that of prekallikrein decreased simultaneously. After two weeks of the disease both these parameters returned to the values obtained in healthy controls. No correlation was observed between the degree of fall of kininogen and prekallikrein levels on the one hand, and the extent of myocardial infarction, on the other. Complications of myocardial infarction in the form of shock and pulmonary oedema affected only the level of kininogen which decreased, while they were without effect on prekallikrein. Kininase activity was reduced in all cases of myocardial infarction and did not change for two weeks. It seems likely that the biological activity of kinins in myocardial infarction may rise owing to their inadaequate breakdown by kininase.
Authors:
B Kolber-Postepska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  17     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1975  
Date Detail:
Created Date:  1976-03-24     Completed Date:  1976-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  169-76     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Kininogens / blood
Kinins / blood*
Lysine Carboxypeptidase / blood
Male
Middle Aged
Myocardial Infarction / blood*,  enzymology
Prekallikrein / blood
Chemical
Reg. No./Substance:
0/Kininogens; 0/Kinins; 9055-02-1/Prekallikrein; EC 3.4.17.3/Lysine Carboxypeptidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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