| Changes in plasma B-type natriuretic peptide after allograft renal transplantation. | |
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MedLine Citation:
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PMID: 17295669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the dynamic changes in plasma B-type natriuretic peptide (BNP) after allograft renal transplantation. METHODS: Plasma BNP was measured in 17 patients before and after unilateral allograft renal transplantation (study group) and in 17 age- and sex-matched healthy individuals (control group). RESULTS: Average BNP level in the study group was significantly higher than in the control group before renal transplantation (P < 0.001). After transplantation, blood pressure was reduced and left ventricular ejection fraction was increased (P < 0.01). There was also a substantial reduction in plasma BNP and blood creatinine following the surgery (P < 0.001). Graft dysfunction accompanied by significant rebound in plasma BNP levels was detected in four patients within 2 weeks of the surgery. CONCLUSION: Plasma BNP levels are elevated in patients with chronic renal failure. Allograft renal transplantation significantly reduces BNP. Sudden increases in plasma BNP after the transplantation are associated with allograft dysfunction. Together with other biomarkers, plasma BNP may be used to predict the changes in renal function after transplantation. |
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Authors:
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Tie-Min Wei; Lie Jin; Ling-Chun Lv; Bao-Jin Zhang; Le-Xin Wang |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Nephrology (Carlton, Vic.) Volume: 12 ISSN: 1320-5358 ISO Abbreviation: Nephrology (Carlton) Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-13 Completed Date: 2007-04-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9615568 Medline TA: Nephrology (Carlton) Country: Australia |
Other Details:
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Languages: eng Pagination: 102-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Lishui City Central Hospital, the 5th Affiliated Hospital of Wenzhou Medical College, Zhejiang Province, China. weitm@lishui.gov.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Case-Control Studies Female Humans Kidney Transplantation* Male Middle Aged Natriuretic Peptide, Brain / blood* Time Factors Transplantation, Homologous Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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