| Changes in phospholipids and free fatty acids in the brains of mice preconditioned by hypoxia. | |
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MedLine Citation:
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PMID: 10494011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in the composition and contents of phospholipids and free fatty acids were observed and compared in three groups: (A) unpreconditoned normal controls, (B) exposure to 1 run of hypoxia and (C) exposure to 4 runs of hypoxia. In group B, the content of phosphatidyl ethanolamine (PE), phosphatidyl serine (PS) and free fatty acids (FFAs) increased significantly and the content of phosphatidyl choline (PC) and sphingomyelin (SM) decreased significantly. While in group C the content of PE, PS, PC and FFAs changed significantly when compared with that of group B, all phospholipid (except SM) and FFA contents tended to decrease to the level of group A. No new FFA was seen in the brain homogenates in any of the three groups. These results suggest that the changes in the content of mouse brain phospholipids and FFAs may be adaptive and involved in the animals' tolerance to hypoxia. |
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Authors:
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C Duan; F Yan; G Lu; H Liu; N Yin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological signals and receptors Volume: 8 ISSN: 1422-4933 ISO Abbreviation: Biol Signals Recept Publication Date: 1999 Jul-Oct |
Date Detail:
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Created Date: 1999-10-20 Completed Date: 1999-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9808792 Medline TA: Biol Signals Recept Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 261-6 Citation Subset: IM |
Affiliation:
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Department of Hygienic-Chemistry, Capital University of Medical Sciences, Beijing, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism* Brain / metabolism* Fatty Acids, Nonesterified / metabolism* Female Ischemic Preconditioning* Male Mice Mice, Inbred BALB C Mice, Inbred Strains Phospholipids / metabolism* Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Phospholipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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