Document Detail

Changes in phospholipids and free fatty acids in the brains of mice preconditioned by hypoxia.
MedLine Citation:
PMID:  10494011     Owner:  NLM     Status:  MEDLINE    
Changes in the composition and contents of phospholipids and free fatty acids were observed and compared in three groups: (A) unpreconditoned normal controls, (B) exposure to 1 run of hypoxia and (C) exposure to 4 runs of hypoxia. In group B, the content of phosphatidyl ethanolamine (PE), phosphatidyl serine (PS) and free fatty acids (FFAs) increased significantly and the content of phosphatidyl choline (PC) and sphingomyelin (SM) decreased significantly. While in group C the content of PE, PS, PC and FFAs changed significantly when compared with that of group B, all phospholipid (except SM) and FFA contents tended to decrease to the level of group A. No new FFA was seen in the brain homogenates in any of the three groups. These results suggest that the changes in the content of mouse brain phospholipids and FFAs may be adaptive and involved in the animals' tolerance to hypoxia.
C Duan; F Yan; G Lu; H Liu; N Yin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological signals and receptors     Volume:  8     ISSN:  1422-4933     ISO Abbreviation:  Biol Signals Recept     Publication Date:    1999 Jul-Oct
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808792     Medline TA:  Biol Signals Recept     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Department of Hygienic-Chemistry, Capital University of Medical Sciences, Beijing, China.
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MeSH Terms
Anoxia / metabolism*
Brain / metabolism*
Fatty Acids, Nonesterified / metabolism*
Ischemic Preconditioning*
Mice, Inbred BALB C
Mice, Inbred Strains
Phospholipids / metabolism*
Reference Values
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Phospholipids

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