Document Detail

Changes in phospholipids in bronchoalveolar lavage fluid of patients with interstitial lung diseases.
MedLine Citation:
PMID:  3146676     Owner:  NLM     Status:  MEDLINE    
We analyzed phospholipids of human bronchoalveolar lavage (BAL) fluids from patients with interstitial lung diseases; idiopathic pulmonary fibrosis (IPF), sarcoidosis, and eosinophilic granuloma (EG) and compared them to those of normal subjects. The content of phospholipid/ml of BAL fluid was significantly decreased in IPF. There was a significant decrease in phosphatidylglycerol (PG) and an increase in phosphatidylinositol (PI) in IPF but not in sarcoidosis and EG. Thus, the PG to PI ratio was significantly decreased in IPF. The dipalmitoyl species of phosphatidylcholine (PC) was found to be significantly decreased in IPF and sarcoidosis by molecular species analysis using high performance liquid chromatography. In contrast, the unsaturated species were increased in these diseases. The decrease in dipalmitoyl PC appeared to be a common feature in interstitial lung diseases. The changes in phospholipids in BAL fluids, especially decreases in DPPC and PG to PI ratio in IPF, appear to indicate that damage of alveolar Type II cells and/or of metabolic disturbance in pulmonary surfactant occurs in IPF.
Y Honda; K Tsunematsu; A Suzuki; T Akino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lung     Volume:  166     ISSN:  0341-2040     ISO Abbreviation:  Lung     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-15     Completed Date:  1989-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Third Department of Internal Medicine, Sapporo Medical College, Japan.
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MeSH Terms
Bronchoalveolar Lavage Fluid / metabolism*
Chromatography, High Pressure Liquid
Phospholipids / metabolism*
Pulmonary Alveoli / metabolism
Pulmonary Fibrosis / metabolism*
Pulmonary Surfactants / metabolism*
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactants

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