| Changes in phospholipid composition of lung surfactant during development in the fetal lamb. | |
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MedLine Citation:
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PMID: 6688364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lung surfactant isolated from pulmonary fluid of fetal sheep changes both in amount and composition during gestation. Total phosphatidylcholine (PC) and its most surface-active components, disaturated PC, are present at very low levels 3-4 weeks prior to term and rise to adult levels 3-4 days before birth. The acidic phospholipids appear with a different time course. Phosphatidylserine reaches elevated levels about 21 days before birth. Phosphatidylinositol begins to increase at about 130 days of gestation. Phosphatidylglycerol is not a component (less than 1%) of the surfactant in this fetal lung fluid. At term, phosphatidylinositol is the major acidic phospholipid found in these fluids. |
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Authors:
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B J Benson; J A Kitterman; J A Clements; E J Mescher; W H Tooley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 753 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 83-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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isolation & purification Animals Chemical Phenomena Chemistry Female Fetus / metabolism Gestational Age Lung / embryology*, enzymology, metabolism Phospholipids / metabolism* Pregnancy Pulmonary Surfactants / metabolism* Sheep / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HL-19185/HL/NHLBI NIH HHS; HL-24075/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phospholipids; 0/Pulmonary Surfactants; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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