Document Detail


Changes in phospholipid composition of lung surfactant during development in the fetal lamb.
MedLine Citation:
PMID:  6688364     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The lung surfactant isolated from pulmonary fluid of fetal sheep changes both in amount and composition during gestation. Total phosphatidylcholine (PC) and its most surface-active components, disaturated PC, are present at very low levels 3-4 weeks prior to term and rise to adult levels 3-4 days before birth. The acidic phospholipids appear with a different time course. Phosphatidylserine reaches elevated levels about 21 days before birth. Phosphatidylinositol begins to increase at about 130 days of gestation. Phosphatidylglycerol is not a component (less than 1%) of the surfactant in this fetal lung fluid. At term, phosphatidylinositol is the major acidic phospholipid found in these fluids.
Authors:
B J Benson; J A Kitterman; J A Clements; E J Mescher; W H Tooley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  753     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / isolation & purification
Animals
Chemical Phenomena
Chemistry
Female
Fetus / metabolism
Gestational Age
Lung / embryology*,  enzymology,  metabolism
Phospholipids / metabolism*
Pregnancy
Pulmonary Surfactants / metabolism*
Sheep / metabolism
Grant Support
ID/Acronym/Agency:
HL-19185/HL/NHLBI NIH HHS; HL-24075/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactants; EC 3.1.3.2/Acid Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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