Document Detail

Changes in phospholipid composition of lung surfactant during development in the fetal lamb.
MedLine Citation:
PMID:  6688364     Owner:  NLM     Status:  MEDLINE    
The lung surfactant isolated from pulmonary fluid of fetal sheep changes both in amount and composition during gestation. Total phosphatidylcholine (PC) and its most surface-active components, disaturated PC, are present at very low levels 3-4 weeks prior to term and rise to adult levels 3-4 days before birth. The acidic phospholipids appear with a different time course. Phosphatidylserine reaches elevated levels about 21 days before birth. Phosphatidylinositol begins to increase at about 130 days of gestation. Phosphatidylglycerol is not a component (less than 1%) of the surfactant in this fetal lung fluid. At term, phosphatidylinositol is the major acidic phospholipid found in these fluids.
B J Benson; J A Kitterman; J A Clements; E J Mescher; W H Tooley
Related Documents :
1802664 - Fetal breathing during chronic lung liquid loss leading to pulmonary hypoplasia.
3658554 - Elastin and collagen in the fetal sheep lung. ii. relationship to mechanical properties...
2919114 - Gestational effects of corticosteroids and surfactant in ventilated rabbits.
1173784 - Effect of metopirone on the synthesis of lung surfactant in does and fetal rabbits.
17145354 - Anatomic and functional changes of the upper urinary tract during pregnancy.
23344414 - Recurrent exophytic meningioma in pregnancy.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  753     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid Phosphatase / isolation & purification
Chemical Phenomena
Fetus / metabolism
Gestational Age
Lung / embryology*,  enzymology,  metabolism
Phospholipids / metabolism*
Pulmonary Surfactants / metabolism*
Sheep / metabolism
Grant Support
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactants; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of maternal diabetes on the levels, synthetic rates and activities of synthetic enzymes of s...
Next Document:  The effect of serum vitamin D-binding protein on polymerization and depolymerization of actin is sim...