| Changes in perfusion-weighted magnetic resonance imaging after carotid angioplasty with stent. | |
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MedLine Citation:
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PMID: 20642890 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carotid artery stenosis due to arteriosclerosis increases the risk of cerebral ischemia via embolic phenomena or reduced blood flow. The changes in cerebral perfusion that may occur after treatment are not clearly understood. This study evaluated the changes in cerebral microcirculation following carotid angioplasty with stenting (CAS) under cerebral protection with filters using ultrafast gradient echo (GRE) perfusion weighted imaging (PWI) with magnetic resonance imaging (MRI). Prospectively, 21 cervical carotid stenosis patients, mean age 69.95 years, underwent MRI 12 h before and 72 h after CAS. PWI parameters were collected for statistical analysis: cerebral blood volume (CBV), mean transit time (MTT) and time to peak (TTP). Statistical analysis was applied to absolute parameters and to values normalized against those from the contralateral parenchyma. The main finding of this study was improved hemodynamics for the normalized data after CAS, shown by reduced MTT (p<0.001) and TTP (p=0.019) in the territory fed by the middle cerebral artery ipsilateral to the CAS. Absolute data showed increased blood volume in the cerebral hemispheres after CAS, which was more accentuated on the stent side (p=0.016) than the contralateral side (p=0.029). Early improvements in cerebral perfusion, mainly seen in the normalized data, were clearly demonstrated in the timing parameters - TTP & MTT - after CAS. |
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Authors:
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A Tavares; J G Caldas; C C Castro; P Puglia; M E Frudit; L A Barbosa |
Publication Detail:
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Type: Journal Article Date: 2010-07-19 |
Journal Detail:
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Title: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Volume: 16 ISSN: 1591-0199 ISO Abbreviation: Interv Neuroradiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-10-07 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 9602695 Medline TA: Interv Neuroradiol Country: Italy |
Other Details:
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Languages: eng Pagination: 161-9 Citation Subset: IM |
Affiliation:
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Universidade de São Paulo, São Paulo, Brazil. antenorts@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angioplasty* Blood Volume Brain Ischemia / pathology, radiography Carotid Stenosis / pathology*, radiography, therapy* Cerebral Angiography Cerebrovascular Circulation* Female Humans Magnetic Resonance Imaging / methods* Male Microcirculation Middle Aged Stents* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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