Document Detail

Changes in the pattern reversal visual evoked potentials in myasthenia gravis.
MedLine Citation:
PMID:  8045249     Owner:  NLM     Status:  MEDLINE    
To investigate the possibility of impaired cholinergic transmission in the Central Nervous System (CNS) in patients with Myasthenia Gravis (MG), the PR-VEPs in 11 newly diagnosed MG patients before and after pyridostigmine treatment compared to those recorded from 10 normal subjects tested in two different occasions one month apart. All patients, (7 female and 4 male) had a good response to treatment. The amplitude of the P100 of the PR-VEPs of the MG patients before and after treatment was significantly lower than those recorded from the normal control subjects and the latency significantly longer. In the patient group the amplitude of the P100 improved significantly after treatment. These results provide neurophysiological evidence of impaired cholinergic transmission in the CNS in patients with MG and suggest that PR-VEPs offer an easily applicable non-invasive method to study the central effects of MG and possibly a procedure to monitor the effectiveness of pyridostigmine treatment.
F Fotiou; D Papakostopoulos; P Hamlatzis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Electromyography and clinical neurophysiology     Volume:  34     ISSN:  0301-150X     ISO Abbreviation:  Electromyogr Clin Neurophysiol     Publication Date:    1994 Apr-May
Date Detail:
Created Date:  1994-08-30     Completed Date:  1994-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0327533     Medline TA:  Electromyogr Clin Neurophysiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Department of Neurology, Medical School, Aristotelian University of Thessaloniki, AHEPA Hospital, Greece.
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MeSH Terms
Cholinergic Fibers / drug effects,  physiology
Evoked Potentials, Visual / drug effects,  physiology*
Follow-Up Studies
Middle Aged
Myasthenia Gravis / drug therapy,  physiopathology*
Pattern Recognition, Visual / physiology*
Photic Stimulation
Pyridostigmine Bromide / therapeutic use
Reaction Time / physiology
Synaptic Transmission / drug effects,  physiology
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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