| Changes in the pattern of microsomal fatty acids in rat liver after thermal injury and therapeutic intervention. | |
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MedLine Citation:
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PMID: 3370512 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite substantial progress in handling the acute phase after thermal injury, severely burned patients still succumb to systemic sepsis as a consequence of a compromised defence system. It is likely that autotoxic mechanisms play an important role in the aetiology of the impaired host defence. One of the primary target systems of autotoxic cell damage is the liver. In the present work oxidative alterations in the microsomal compartment of liver cells have been investigated. It was found that thermal burns are associated with extensive oxidation of polyunsaturated fatty acids which can be antagonized by antioxidants such as silibinin. |
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Authors:
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K H Schmidt; U Müller; W Hörer; R Braatz |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Burns, including thermal injury Volume: 14 ISSN: 0305-4179 ISO Abbreviation: Burns Incl Therm Inj Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-06-30 Completed Date: 1988-06-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7512054 Medline TA: Burns Incl Therm Inj Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 25-30 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Tuebingen, FR Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / therapeutic use* Burns / complications*, drug therapy Fatty Acids / metabolism* Fatty Acids, Unsaturated / metabolism Male Microsomes, Liver / metabolism* Rats Rats, Inbred Strains Silymarin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Silymarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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