Document Detail

Changes in the patching and capping of insulin receptors under the influence of hormonal imprinting.
MedLine Citation:
PMID:  3063696     Owner:  NLM     Status:  MEDLINE    
Binding of fluorescein-isothiocyanate-(FITC)-labeled insulin was followed up in the function of time in Chang liver cells pretreated and not pretreated with insulin. The not pretreated cells showed patching, but no capping of the receptors during the period of study (60 min), whereas the insulin-pretreated cells showed indications of capping already after 10 min. Patching of the insulin receptors was particularly conspicuous at the sites of cell-cell contact (at the intercellular junctions). Supra-nuclear patching occurred earlier in the control cultures, and on it followed the fluorescence of the nuclear chromatin.
P Kovács; O Török; G Csaba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histochemistry     Volume:  90     ISSN:  0301-5564     ISO Abbreviation:  Histochemistry     Publication Date:  1988  
Date Detail:
Created Date:  1989-03-08     Completed Date:  1989-03-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0411300     Medline TA:  Histochemistry     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Department of Biology, Semmelweis University of Medicine, Budapest, Hungary.
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MeSH Terms
Cells, Cultured
Insulin / metabolism,  pharmacology*
Liver / cytology,  drug effects,  metabolism*
Receptor Aggregation / drug effects*
Receptor, Insulin / drug effects,  metabolism*
Time Factors
Reg. No./Substance:
11061-68-0/Insulin; EC, Insulin

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