Document Detail

Changes in oxygen uptake-work rate relationship as a compensatory mechanism in patients with heart failure.
MedLine Citation:
PMID:  1602599     Owner:  NLM     Status:  MEDLINE    
To assess the compensatory change in oxygen uptake (VO2) kinetics during exercise in patients with heart failure, we performed cardiopulmonary exercise testing using a cycle ergometer in 29 cardiac patients and 18 normal subjects. The work rate increased linearly (1w/6sec) after a 4 min, 20w warm-up. The ratio of increase in VO2 to increase in work rate (delta VO2/delta WR) was determined by linear regression of VO2 plots. Cardiac output by dye dilution method and plasma norepinephrine concentration (NE) were measured at rest and 20w warm-up. VO2 at rest and at 20w warm-up and delta VO2/delta WR decreased significantly with increasing severity in NYHA functional classification. delta VO2/delta WR showed significant negative correlation to the difference in NE levels at rest and at 20w (r = -0.69, p less than 0.001). The delta values of arteriovenous O2 content difference, calculated using Fick's principle, and cardiac index from rest to 20w warm-up failed to show significant relationship to delta VO2/delta WR. These results suggest that the decrease in VO2 requirement in heart failure patients is due probably to blood redistribution during exercise as a compensatory mechanism for exercise intolerance.
H Itoh; M Nakamura; C Ikeda; E Yanagisawa; F Hatogai; M Iwadare; K Taniguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  56     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-14     Completed Date:  1992-07-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  504-8     Citation Subset:  IM    
Cardiovascular Institute Hospital, Tokyo, Japan.
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MeSH Terms
Cardiac Output
Exercise Test
Heart Failure / metabolism,  physiopathology*
Middle Aged
Norepinephrine / blood
Oxygen / metabolism*
Physical Exertion*
Regression Analysis
Reg. No./Substance:
51-41-2/Norepinephrine; 7782-44-7/Oxygen

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