| Changes in the organization of the ventroposterior lateral thalamic nucleus after digit removal in adult raccoon. | |
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MedLine Citation:
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PMID: 8789278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ventroposterior lateral nucleus of the thalamus was studied in seven raccoons that had undergone amputation of the fourth digit between 2 and 5 months previously. Extracellular recordings were made in a series of closely spaced penetrations through the thalamus in chloralose anesthetized animals. The responses to cutaneous stimulation of the forepaw were used to reconstruct the somatotopic organization of the thalamus and to identify recording sites believed to be located in the digit zone that had lost its peripheral input. Twelve penetrations that passed through both of the adjacent fifth and third digit regions were analyzed in detail to delineate this deafferented region. None of the recording sites in this region were completely silent, indicating that the deafferented thalamus had undergone significant reorganization of its inputs. At most sites, the neurons had receptive fields on the skin surrounding the amputation wound and including one of the adjacent digits. Approximately half of the sites had low thresholds in the range of normal thalamic neurons. These results indicate that the ventroposterior thalamus is capable of substantial reorganization, which may account for much of the reorganization seen in somatosensory cortex. |
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Authors:
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D Rasmusson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of comparative neurology Volume: 364 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-10-23 Completed Date: 1996-10-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 92-103 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Afferent Pathways
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physiology Age Factors Animals Brain Mapping* Denervation Female Humans Male Neuronal Plasticity / physiology* Raccoons / physiology* Thalamic Nuclei / physiology* Thalamus / physiology, ultrastructure Toes / innervation, surgery |
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