Document Detail

Changes in neurocan expression in the distal spinal cord stump following complete cord transection: a comparison between infant and adult rats.
MedLine Citation:
PMID:  12573465     Owner:  NLM     Status:  MEDLINE    
The distal transected cords of infant rats are more permissive for axon extension than those of adults. To elucidate the biomolecular basis for this phenomenon, we examined the expression pattern of neurocan using semi-quantitative reverse transcription polymerase chain reaction and immunostaining in the distal cord of both adult and infant rats after transection. Neurocan is a chondroitin sulfate proteoglycan with well-documented axon growth-inhibitory properties in the central nervous system. Neurocan mRNA was up-regulated in the distal cord of adult rats shortly after transection, followed by a longer wide distribution of neurocan immunoreactivity (IR) in both neurons and astrocytes; by contrast, upregulation of neurocan mRNA was not seen in infant rats, although transient expression of neurocan IR was seen in neurons. Combined with the different regenerative capacity of infant and adult rats, the present results suggest that neurocan inhibits spinal cord regeneration.
Mei-Ling Qi; Yoshiaki Wakabayashi; Mitsuhiro Enomoto; Kenichi Shinomiya
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience research     Volume:  45     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-04-10     Revised Date:  2008-05-13    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  181-8     Citation Subset:  IM    
Section of Orthopaedic and Spinal Surgery, Department of Frontier Surgical Therapeutics, Division of Advanced Therapeutical Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519 Tokyo, Japan.
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MeSH Terms
Age Factors
Animals, Newborn
Gene Expression Regulation / physiology*
Lectins, C-Type
Nerve Tissue Proteins / analysis,  biosynthesis*
Proteochondroitin Sulfates / analysis,  biosynthesis*
RNA, Messenger / analysis,  biosynthesis
Rats, Sprague-Dawley
Spinal Cord / chemistry,  metabolism*
Spinal Cord Injuries / metabolism*
Thoracic Vertebrae / chemistry,  metabolism
Reg. No./Substance:
0/Lectins, C-Type; 0/Nerve Tissue Proteins; 0/Proteochondroitin Sulfates; 0/RNA, Messenger; 148684-98-4/NCAN protein, human

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