| Changes in nasal mucosal blood flux and air-flow resistance on unilateral histamine challenge. | |
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MedLine Citation:
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PMID: 8508545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate reflex vascular control in the nose, we challenged each side of the nose with 0.9% saline and histamine (0.3 mg aqueous) and observed changes in unilateral nasal airway resistance (Rnaw) and laser doppler flux (LDF) in response to contra-lateral and ipsilateral challenge in eight normal subjects. Preliminary studies demonstrated that the preferred site for observation of LDF was the nasal septum (same-day concordance 0.920; inferior turbinate 0.307). Ipsilateral contra-lateral saline induced no significant change to either parameter. Ipsilateral histamine produced a highly significant rise in LDF (757 arbitrary units SEM 94 at 3 min; baseline 489 SEM 75: P < 0.05) and Rnaw (baseline: 3.10, SEM 0.52; 5 min: 8.81, SEM 2.09 cmH2O/l/s: P < 0.01). Contra-lateral histamine produced a significant P < 0.05) fall in both (LDF 317, SEM 24 at 3 min; Rnaw 2.67, SEM 0.78 cm H2O/l/s at 6 min). This previously unrecorded observation suggests a neural reflex that increases the patency of the contra-lateral nostril after unilateral obstruction is provoked. |
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Authors:
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M A Birchall; R C Schroter; N B Pride |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical otolaryngology and allied sciences Volume: 18 ISSN: 0307-7772 ISO Abbreviation: Clin Otolaryngol Allied Sci Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-07-15 Completed Date: 1993-07-15 Revised Date: 2005-05-02 |
Medline Journal Info:
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Nlm Unique ID: 7701793 Medline TA: Clin Otolaryngol Allied Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 139-44 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Resistance / drug effects* Bronchial Provocation Tests Female Histamine / analogs & derivatives, diagnostic use*, pharmacology Humans Laser-Doppler Flowmetry Male Middle Aged Nasal Mucosa / blood supply* Nasal Septum / blood supply |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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