Document Detail

Changes in the morphology and components of the coronary arteries during the progression of coronary arteriosclerosis following cardiac transplantation in rats.
MedLine Citation:
PMID:  9705103     Owner:  NLM     Status:  MEDLINE    
In order to examine the changes in coronary artery morphology following cardiac transplantation, the intimal and medial areas and vascular components were measured 30 and 60 days postoperatively in rats receiving both iso- (n = 5, each time) and allotransplantations (n = 7, each time). Although cyclosporine A was administered intramuscularly (10 mg/kg per day) for 20 days following transplantation, graft rejection progressed gradually in the allotransplanted group. There were no clear changes in the intimal or medial areas following transplantation in the isotransplanted group. The intimal area of the coronary arteries in the allograft group was significantly thicker 30 and 60 days following transplantation, while the medial area of the coronary arteries in this group was significantly thinner than that of the isotransplantation group at these same time points. In the thickened intimal areas in the allotransplantation group, only the density of smooth muscle cells was higher following transplantation. In the thinned medial areas in the allotransplantation group, the densities of the smooth muscle cells and collagen were less than those in the isotransplantation group. These changes suggest that following transplantation, smooth muscle cells proliferate in the intimal areas, while smooth muscle cells and collagen are degraded in the medial areas.
K Hamano; H Ito; Y Fujimura; H Tsuboi; K Esato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular surgery (London, England)     Volume:  6     ISSN:  0967-2109     ISO Abbreviation:  Cardiovasc Surg     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-07     Completed Date:  1998-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9308765     Medline TA:  Cardiovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Yamaguchi University School of Medicine, First Department of Surgery, Ube, Japan.
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MeSH Terms
Cell Division
Coronary Artery Disease / pathology*
Coronary Vessels / pathology*
Disease Progression
Heart Transplantation / pathology*
Muscle, Smooth, Vascular / pathology
Rats, Inbred F344
Rats, Inbred Lew
Tunica Intima / pathology

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