Document Detail


Changes in monoamine turnover in forebrain areas associated with masculine sexual behavior: a microdialysis study.
MedLine Citation:
PMID:  7532094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report compares the changes in the main dopamine (DA) and serotonin (5-HT) metabolites, respectively dihydroxyphenylacetic acid (DOPAC) and 5-hydroxy indoleacetic acid (5-HIAA) in three relatively close brain regions, namely the nucleus accumbens (ACB), the medial preoptic area, and the medial basal hypothalamus (MBH), as well as DA in the ACB, of copulating male rats. All these neurochemicals remained fairly stable when the animals were exposed to non sexual social stimuli (castrated females), and they increased during mating with receptive females. There were regional differences in these copulation-related changes, however, with those in the MBH being shorter-lived. There were also differences in the time-course of the changes in DOPAC and 5-HIAA the latter being slower. It is suggested that they reflect the involvement of the DA and 5-HT innervation of diencephalic structures in, respectively the appetitive and consummatory/satiation mechanisms of sexual behavior. The physiological relevance of these neurochemical changes is supported by the lack of differences between the standard measures for sexual behavior recorded before surgery and during the dialysis session.
Authors:
B Fumero; J R Fernandez-Vera; J L Gonzalez-Mora; M Mas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  662     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-03-22     Completed Date:  1995-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  233-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of La Laguna, Medical School, Tenerife, Spain.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Biogenic Monoamines / metabolism*
Dopamine / physiology
Hydroxyindoleacetic Acid / metabolism
Hypothalamus, Middle / metabolism
Male
Microdialysis
Nucleus Accumbens / metabolism
Orchiectomy
Preoptic Area / metabolism
Prosencephalon / metabolism*
Rats
Rats, Sprague-Dawley
Serotonin / physiology
Sexual Behavior, Animal / physiology*
Chemical
Reg. No./Substance:
0/Biogenic Monoamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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