| Changes in monoamine metabolites concentrations in rat cerebrospinal fluid after acute and long-term administration of a selective serotonin reuptake inhibitor, trazodone. | |
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MedLine Citation:
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PMID: 10660949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1 p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons. |
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Authors:
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T Egashira; F Takayama; Y Yamanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 40 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-02-17 Completed Date: 2000-02-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 503-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Oita Medical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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cerebrospinal fluid* Animals Homovanillic Acid / cerebrospinal fluid* Hydroxyindoleacetic Acid / cerebrospinal fluid* Male Methoxyhydroxyphenylglycol / cerebrospinal fluid* Rats Rats, Wistar Serotonin Uptake Inhibitors / pharmacology* Trazodone / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Uptake Inhibitors; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 19794-93-5/Trazodone; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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