Document Detail

Changes in monoamine metabolites concentrations in rat cerebrospinal fluid after acute and long-term administration of a selective serotonin reuptake inhibitor, trazodone.
MedLine Citation:
PMID:  10660949     Owner:  NLM     Status:  MEDLINE    
In order to clarify the mechanism of the antidepressive effects of trazodone, a selective serotonin reuptake inhibitor, we investigated the dynamics of monoamine metabolites in cerebrospinal fluid (CSF) of free-moving conscious rats by acute and long-term treatment with trazodone. When 100 mg kg-1 p.o. of trazodone were administered, a significant increase of 3-methoxy-4-hydroxyphenylglycol (MHPG) concentration was soon observed in the light period of the light/dark cycle, and a significant decrease of dihydroxy phenyl acetic acid (DOPAC) concentration was observed during the 2 days after administration of trazodone; in contrast, the homovanilic acid (HVA) level was increased. However, we detected no significant changes in the 5-hydroxy indole-3-acetic acid (5-HIAA) concentration during the 3 days. In the case of long-term treatment with 50 mg kg-1, p.o. of trazodone, the levels of MHPG, DOPAC and HVA exhibited no difference when compared with values obtained during saline treatment in either the light or dark period, whereas the levels of 5-HIAA showed a significant increase during the light period. These findings suggest that a long-term treatment with trazodone enhances the serotonergic neurons.
T Egashira; F Takayama; Y Yamanaka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  40     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Department of Pharmacology, Oita Medical University, Japan.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid*
Homovanillic Acid / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Methoxyhydroxyphenylglycol / cerebrospinal fluid*
Rats, Wistar
Serotonin Uptake Inhibitors / pharmacology*
Trazodone / pharmacology*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 19794-93-5/Trazodone; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid

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