| Changes in molecular weight of hyaluronan and hyaluronidase activity in uterine cervical mucus in cervical ripening. | |
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MedLine Citation:
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PMID: 11380283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study was undertaken to investigate changes in the forms of hyaluronan and hyaluronidase activity in cervical mucus during cervical ripening. METHODS: Uterine cervical mucus was obtained from 57 pregnant women (25 at preterm gestation, ten at term gestation, 11 within 1 week before labor, and 11 during the first stage of labor). We determined 1) concentration of hyaluronan, 2) hyaluronidase activity, and 3) molecular weight of hyaluronan in cervical mucus. Data are presented as mean and range. RESULTS: The hyaluronan concentration in mucus in the 1st stage of labor (1.58 microg/ml, 0.46-23.96) was significantly (p<0.05) higher than that in all other groups (preterm: 0.29, 0.10-0.88; term: 0.24, 0.11-0.80; within 1 week before labor: 0.30, 0.18-0.62). Hyaluronidase activity both within 1 week before labor group (3.03 min., 1.12-3.95) and in 1st stage of labor group (3.52, 0.43-5.15) was significantly (p<0.05) higher than that in preterm group (1.70, 0.00-5.47). The molecular weight of hyaluronan in cervical mucus in the 1st stage of labor (0.97x106, 0.86-1.41) was significantly (p<0.05) lower than in the preterm and term groups (preterm: 1.60, 1.21-2.20, term: 1.41, 1.21-2.20). There was a significant correlation between hyaluronidase activity and molecular weight of hyaluronan (p<0.05, r=-0.41, n=23). CONCLUSION: These findings suggest that either hyaluronidase or low-molecular weight hyaluronan could be one of the most important regulators in the process of cervical ripening. |
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Authors:
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M Obara; H Hirano; M Ogawa; H Tsubaki; N Hosoya; Y Yoshida; S Miyauchi; T Tanaka |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 80 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-30 Completed Date: 2001-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 492-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Biological Markers / analysis Cervical Ripening / metabolism, physiology* Cervix Mucus / chemistry*, enzymology* Chromatography, High Pressure Liquid Female Gestational Age Humans Hyaluronic Acid / analysis*, metabolism Hyaluronoglucosaminidase / analysis*, metabolism Labor Stage, First Labor Stage, Third Molecular Weight Pregnancy Probability Prospective Studies Sensitivity and Specificity Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9004-61-9/Hyaluronic Acid; EC 3.2.1.35/Hyaluronoglucosaminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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