| Changes in mitochondrial lipids of rat kidney during ischemia. | |
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MedLine Citation:
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PMID: 7378435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid changes in mitochondria isolated from rat kidney after various periods of ischemia were analysed by thin-layer chromatography and gas-liquid chromatography. Free fatty acids were increased at 30 min and more so thereafter. Total phospholipid fatty acids decreased steadily. The proportion of diphosphatidylglycerol (cardiolipin) in the total phospholipid fraction decreased at 30 min, but the proportion of phosphatidylcholine and phosphatidylethanolamine in the total phospholipid fraction did not change until the irreversible phase of ischemic injury. We have shown that decrease of cardiolipin in mitochondrial membrane occurs early during ischemia, and only during the irreversible phase of ischemia are phosphatidylethanolamine and phosphatidylcholine broken down. It is postulated that these phenomena are due to activation of phospholipase in the mitochondrial membrane. |
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Authors:
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M W Smith; Y Collan; M W Kahng; B F Trump |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 618 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-08-28 Completed Date: 1980-08-28 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 192-201 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fatty Acids, Nonesterified / metabolism Ischemia / physiopathology* Kidney / blood supply, metabolism* Lipid Metabolism* Male Microscopy, Electron Mitochondria / metabolism*, ultrastructure Rats |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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