Document Detail

Changes in the microstructure of feeding after administration of enterostatin into the paraventricular nucleus and the amygdala.
MedLine Citation:
PMID:  9533645     Owner:  NLM     Status:  MEDLINE    
The effects of enterostatin (ENT) injected into the paraventricular nucleus (PVN) and the amygdala (AMYG) on the microstructure of feeding was studied by using an automated feeding apparatus. In rats adapted to a 6-h meal feeding regime, ENT reduced the size and duration of the first meal after injection in both the PVN and the AMYG. Similar effects were observed when ENT was given at the beginning of the dark cycle in rats fed ad libitum although the onset of feeding was also delayed in this situation. The number of meals and the size of subsequent meals was unaffected by ENT but the eating rate within the first meal was reduced after ENT injection into the AMYG of meal-fed rats. Enterostatin injected into the AMYG at a dose that suppressed feeding did not produce a conditioned taste aversion. ENT given centrally therefore appears to reduce food intake by delaying the initiation of feeding and/or advancing meal termination suggesting that it affects both appetite and satiation mechanisms.
L Lin; D A York
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  19     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-08     Completed Date:  1998-05-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  557-62     Citation Subset:  IM    
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.
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MeSH Terms
Amygdala / drug effects*
Appetite / drug effects
Colipases / administration & dosage*
Enzyme Precursors
Feeding Behavior / drug effects*
Paraventricular Hypothalamic Nucleus / drug effects*
Protein Precursors / administration & dosage*
Satiation / drug effects
Grant Support
Reg. No./Substance:
0/Colipases; 0/Enzyme Precursors; 0/Protein Precursors; 72994-53-7/procolipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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