Document Detail


Changes in microcirculation as early markers for infection in preterm infants--an observational prospective study.
MedLine Citation:
PMID:  19581833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In adults with severe sepsis, the disturbances of the sublingual microcirculation can be quantified with orthogonal polarization spectral imaging. We investigated the cutaneous microcirculation of preterm infants with proven infection (PosInf) and with suspected but unproven infection (NegInf). In 25 infants, orthogonal polarization spectral images were obtained daily, videos of the images were blinded, and analyzed off-line. Functional small vessel density (FSVD) was prospectively calculated from day 3 to day 30 of life. There were 17 episodes of proven and nine episodes of suspected but unproven nosocomial late onset infection. Four infants remained healthy. The data were analyzed for the 5 d before the start of antibiotics (day -5 until day -1). FSVD varied widely, but in the PosInf-group, we found a 10% decline from day -5 to day -1 (p = 0.013). There was no significant change over time in the NegInf-group (p = 0.58). Thus, in infants with proven infection, FSVD decreases already 1 d before changes in laboratory parameters. However, these changes in FSVD during infection are not represented by absolute values, but must be identified by daily intraindividual observation.
Authors:
Kathrin Weidlich; Julia Kroth; Claudia Nussbaum; Stephan Hiedl; Andreas Bauer; Frank Christ; Orsolya Genzel-Boroviczeny
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-02-05     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, General Hospital Munich, Munich Bavaria 80804, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / metabolism*
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / diagnosis,  metabolism*
Microcirculation*
Prospective Studies
Regional Blood Flow
Sepsis / blood*
Skin / blood supply*
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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