| Changes in membrane fluidity induced by tryptophan and its metabolites. | |
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MedLine Citation:
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PMID: 10721077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Incorporation of fatty acids into phospholipids as well as cholesterol and phospholipid concentration has been investigated using samples of rat liver homogenate, Krebs-Ringer-phosphate buffer (pH = 7.4), containing 0.3% albumin, fatty acid mixture and glycerol. The addition of kynurenine, kynurenic, xanthurenic, picolinic, and 5-hydroxyindoleacetic acids to incubation medium for phospholipid biosynthesis in vitro induced the elevation of cholesterol/phospholipid ratio, cholesterol concentration in samples, an increase of saturated and a decrease of polyunsaturated fatty acids, especially arachidonic acid incorporation into phospholipids. It allowed us to suggest that these metabolites of tryptophan can decrease the membrane fluidity, depress cell cycle, cell transformation and may stimulate cholesterol precipitation. The addition of tryptophan, 3-hydroxykynurenine, 3-hydroxyanthranilic, quinolinic, nicotinic acids, serotonin together with iproniasid, acetylserotonin, and melatonin to incubation medium for phospholipid biosynthesis in vitro induced an inverse relationship. Tryptophan and above mentioned metabolites decreased cholesterol/phospholipid ratio, cholesterol concentration in samples and incorporation of saturated fatty acids into phospholipids. The incorporation of polyunsaturated fatty acids, especially arachidonic acid increased. It allowed us to suggest that tryptophan and these metabolites, may increase membrane fluidity, stimulate cell cycle, cell transformation and can protect against cholesterol precipitation. |
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Authors:
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V Rudzite; E Jurika; J Jirgensons |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 467 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-05-09 Completed Date: 2000-05-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 353-67 Citation Subset: IM |
Affiliation:
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Latvia Institute of Cardiology, Laboratory of Biochemistry, Riga, Latvia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / drug effects Cell Membrane / drug effects, metabolism Cholesterol / metabolism Fatty Acids / metabolism Hydroxyindoleacetic Acid / pharmacology Kinetics Kynurenic Acid / pharmacology Kynurenine / pharmacology Liver / cytology, drug effects*, metabolism Male Membrane Fluidity / drug effects*, physiology Membrane Lipids / metabolism Phospholipids / biosynthesis, metabolism Picolinic Acids / pharmacology Rats Rats, Wistar Tryptophan / analogs & derivatives*, pharmacology* Xanthurenates / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Membrane Lipids; 0/Phospholipids; 0/Picolinic Acids; 0/Xanthurenates; 343-65-7/Kynurenine; 492-27-3/Kynurenic Acid; 54-16-0/Hydroxyindoleacetic Acid; 57-88-5/Cholesterol; 59-00-7/xanthurenic acid; 73-22-3/Tryptophan; 98-98-6/picolinic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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