| Changes in matrix phosphorylation during bovine dentin development. | |
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MedLine Citation:
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PMID: 17697169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphorylation of the organic matrix proteins of dentin is important for the initiation of mineralization, but its relevance in later mineralization stages is controversial. The objective of this study was to analyze changes in the total matrix phosphate content during dentin development and to identify their origin. Amino acid and total matrix phosphate analyses of microdissected developing mantle and circumpulpal fetal bovine dentin specimens were performed. The amino acid composition showed few changes during mantle and circumpulpal dentin maturation. However, the total matrix phosphate content showed a significant, positive correlation with tissue maturation in both mantle and circumpulpal dentin, with a two- and a three-fold increase, respectively, being observed. The data indicate that changes occur in the pattern of phosphorylation of matrix proteins during dentin maturation, which we suggest may play a functional role in later stages of tooth mineralization. |
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Authors:
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Kostas Verdelis; Lyudmilla Lukashova; Mitsuo Yamauchi; Peter Atsawasuwan; John T Wright; Margaret G E Peterson; Divya Jha; Adele L Boskey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: European journal of oral sciences Volume: 115 ISSN: 0909-8836 ISO Abbreviation: Eur. J. Oral Sci. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-10-26 Revised Date: 2013-06-06 |
Medline Journal Info:
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Nlm Unique ID: 9504563 Medline TA: Eur J Oral Sci Country: Denmark |
Other Details:
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Languages: eng Pagination: 296-302 Citation Subset: D; IM |
Affiliation:
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The Hospital for Special Surgery, 535 E. 70th Street, New York, NY 10021, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Amino Acids / metabolism* Animals Cattle Dentin / chemistry*, embryology Extracellular Matrix Proteins / metabolism* Female Incisor / chemistry*, embryology Phosphates / metabolism* Phosphoproteins / metabolism Phosphorylation Pregnancy Sialoglycoproteins |
| Grant Support | |
ID/Acronym/Agency:
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AR 046121/AR/NIAMS NIH HHS; C06 RR 12538/RR/NCRR NIH HHS; DE 04141/DE/NIDCR NIH HHS; DE 08467/DE/NIDCR NIH HHS; DE 10489/DE/NIDCR NIH HHS; R01 DE004141-31A1/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/DMP1 protein, human; 0/Extracellular Matrix Proteins; 0/Phosphates; 0/Phosphoproteins; 0/Sialoglycoproteins; 0/dentin sialophosphoprotein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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