Document Detail


Changes in matrix phosphorylation during bovine dentin development.
MedLine Citation:
PMID:  17697169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phosphorylation of the organic matrix proteins of dentin is important for the initiation of mineralization, but its relevance in later mineralization stages is controversial. The objective of this study was to analyze changes in the total matrix phosphate content during dentin development and to identify their origin. Amino acid and total matrix phosphate analyses of microdissected developing mantle and circumpulpal fetal bovine dentin specimens were performed. The amino acid composition showed few changes during mantle and circumpulpal dentin maturation. However, the total matrix phosphate content showed a significant, positive correlation with tissue maturation in both mantle and circumpulpal dentin, with a two- and a three-fold increase, respectively, being observed. The data indicate that changes occur in the pattern of phosphorylation of matrix proteins during dentin maturation, which we suggest may play a functional role in later stages of tooth mineralization.
Authors:
Kostas Verdelis; Lyudmilla Lukashova; Mitsuo Yamauchi; Peter Atsawasuwan; John T Wright; Margaret G E Peterson; Divya Jha; Adele L Boskey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  European journal of oral sciences     Volume:  115     ISSN:  0909-8836     ISO Abbreviation:  Eur. J. Oral Sci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-10-26     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  9504563     Medline TA:  Eur J Oral Sci     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  296-302     Citation Subset:  D; IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Amino Acids / metabolism*
Animals
Cattle
Dentin / chemistry*,  embryology
Extracellular Matrix Proteins / metabolism*
Female
Incisor / chemistry*,  embryology
Phosphates / metabolism*
Phosphoproteins / metabolism
Phosphorylation
Pregnancy
Sialoglycoproteins
Grant Support
ID/Acronym/Agency:
AR 046121/AR/NIAMS NIH HHS; C06 RR 12538/RR/NCRR NIH HHS; DE 04141/DE/NIDCR NIH HHS; DE 08467/DE/NIDCR NIH HHS; DE 10489/DE/NIDCR NIH HHS; R01 DE004141/DE/NIDCR NIH HHS; R01 DE004141-31A1/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/DMP1 protein, human; 0/Extracellular Matrix Proteins; 0/Phosphates; 0/Phosphoproteins; 0/Sialoglycoproteins; 0/dentin sialophosphoprotein
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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