Document Detail

Changes in manganese content of mononuclear blood cells in patients receiving total parenteral nutrition.
MedLine Citation:
PMID:  8174259     Owner:  NLM     Status:  MEDLINE    
We measured the manganese content of mononuclear blood cells and the manganese concentrations in whole blood and plasma from 31 healthy volunteers and 25 patients receiving total parenteral nutrition (TPN) (i.e., no dietary manganese). The manganese content (mean +/- 2 SD) of mononuclear blood cells and the manganese concentration in whole blood and plasma in the healthy volunteers were 8.84 +/- 4.18 ng/10(8) cells, 11.21 +/- 4.68 micrograms/L, and 1.21 +/- 0.72 micrograms/L, respectively. The manganese content of mononuclear blood cells from patients receiving TPN gradually decreased, falling below the lowest limit of the normal range by 21 weeks (95% confidence limits, 13-30 weeks) after starting TPN. Manganese concentrations in whole blood and plasma were within normal limits during our study period. These results suggest that the manganese content of mononuclear blood cells may better indicate manganese nutritional status than whole-blood or plasma concentrations.
A Matsuda; M Kimura; T Takeda; M Kataoka; M Sato; Y Itokawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  40     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-08     Completed Date:  1994-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-32     Citation Subset:  IM    
Research Laboratories, Roussel Morishita Co., Ltd., Shiga, Japan.
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MeSH Terms
Aged, 80 and over
Leukocytes, Mononuclear / metabolism*
Manganese / administration & dosage,  analysis,  blood*
Middle Aged
Nutritional Status
Parenteral Nutrition, Total*
Reference Values
Reg. No./Substance:

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