Document Detail

Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis.
MedLine Citation:
PMID:  17148544     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess changes in macrophage phenotype and function after rituximab-induced B cell depletion in patients with rheumatoid arthritis (RA). METHODS: 10 patients with RA were treated with rituximab, achieving significant B cell depletion 4 months later. Clinical improvement, rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) antibodies, mRNA of B cell activating factor (BAFF), interleukin (IL) 10 and CD86 in human monocyte-derived macrophages (HMDMs) and tumour necrosis factor alpha (TNFalpha) secretion from cultured HMDMs were assessed at baseline and after the depletion. RESULTS: A clinical response of American College of Rheumatology (ACR) 50% improvement was noted in six patients, and another two patients responded with moderate improvement, equivalent to ACR 20-50% improvements. RF and anti-CCP antibodies were positive at baseline in seven of ten patients. RF disappeared or declined in six patients 4 months after treatment, correlating with clinical improvement. By contrast, anti-CCP remained unchanged in six patients. After rituximab treatment, and in association with clinical improvement, BAFF, IL10 and CD86 mRNA expression in HMDM were significantly upregulated compared with values at baseline. A significant decrease in TNFalpha in the supernatant of cultured HMDM was also noted. CONCLUSIONS: In addition to B cell depletion and attenuation in some of the specific autoantibodies, clinical improvement in rituximab-treated patients with RA occurred in association with changes in macrophage function.
E Toubi; A Kessel; G Slobodin; N Boulman; E Pavlotzky; D Zisman; M Rozenbaum; I Rosner
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Publication Detail:
Type:  Journal Article     Date:  2006-12-05
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  66     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-06-19     Revised Date:  2010-09-15    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  818-20     Citation Subset:  IM    
Division of Clinical Immunology and Allergy, Bnai Zion Medical Center, P O Box 4940, Haifa 31048, Israel.
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MeSH Terms
Antibodies, Monoclonal / pharmacology*,  therapeutic use
Antigens, CD86 / biosynthesis
Antirheumatic Agents / pharmacology*,  therapeutic use
Arthritis, Rheumatoid / drug therapy*,  immunology
Autoantibodies / blood
B-Cell Activating Factor / biosynthesis
B-Lymphocytes / drug effects
Cells, Cultured
Interleukin-10 / biosynthesis
Lymphocyte Count
Lymphocyte Depletion
Macrophages / drug effects*,  immunology
Middle Aged
Peptides, Cyclic / immunology
Rheumatoid Factor / blood
Severity of Illness Index
Treatment Outcome
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, CD86; 0/Antirheumatic Agents; 0/Autoantibodies; 0/B-Cell Activating Factor; 0/Peptides, Cyclic; 0/Tumor Necrosis Factor-alpha; 0/cyclic citrullinated peptide; 0/rituximab; 130068-27-8/Interleukin-10; 9009-79-4/Rheumatoid Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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