| Changes in lymphocyte subsets during normal pregnancy. | |
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MedLine Citation:
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PMID: 9481564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral blood lymphocytes from healthy women were studied during pregnancy and postnatally, and were compared with lymphocytes from an age-matched non-pregnant control group. Compared with non-pregnant women, the total white cell count was significantly increased at all pregnancies and also post-partum. In pregnancy the absolute number and percentage of T lymphocytes was slightly elevated while almost no changes in B cells were found. No significant changes were found in the percentage of suppressor/cytotoxic (CD8+), of helper/inducer (CD4+) T lymphocytes, nor of CD4+/CD8+ ratio at any stage of pregnancy and puerperium. The most remarkable changes of the immune system occurred in the group of HLA-DR+ and CD56+ activated T cells. The cell numbers showed a significant increase in the first trimester (< 14 weeks) and decreased slightly from stage to stage. Lower values in NK (natural killer) cells and higher levels of IL-2 receptor positive T lymphocytes did not reach significant levels of change. |
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Authors:
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M Kühnert; R Strohmeier; M Stegmüller; E Halberstadt |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 76 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 147-51 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics, University Hospital Frankfurt/Main, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD56 / immunology B-Lymphocytes Female Flow Cytometry HLA-DR Antigens / immunology Humans Killer Cells, Natural Lymphocyte Activation Lymphocyte Count Lymphocyte Subsets* Pregnancy / blood*, immunology Reference Values T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD56; 0/HLA-DR Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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