Document Detail

Changes in lymphocyte subsets during normal pregnancy.
MedLine Citation:
PMID:  9481564     Owner:  NLM     Status:  MEDLINE    
Peripheral blood lymphocytes from healthy women were studied during pregnancy and postnatally, and were compared with lymphocytes from an age-matched non-pregnant control group. Compared with non-pregnant women, the total white cell count was significantly increased at all pregnancies and also post-partum. In pregnancy the absolute number and percentage of T lymphocytes was slightly elevated while almost no changes in B cells were found. No significant changes were found in the percentage of suppressor/cytotoxic (CD8+), of helper/inducer (CD4+) T lymphocytes, nor of CD4+/CD8+ ratio at any stage of pregnancy and puerperium. The most remarkable changes of the immune system occurred in the group of HLA-DR+ and CD56+ activated T cells. The cell numbers showed a significant increase in the first trimester (< 14 weeks) and decreased slightly from stage to stage. Lower values in NK (natural killer) cells and higher levels of IL-2 receptor positive T lymphocytes did not reach significant levels of change.
M Kühnert; R Strohmeier; M Stegmüller; E Halberstadt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  76     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Department of Gynecology and Obstetrics, University Hospital Frankfurt/Main, Germany.
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MeSH Terms
Antigens, CD56 / immunology
Flow Cytometry
HLA-DR Antigens / immunology
Killer Cells, Natural
Lymphocyte Activation
Lymphocyte Count
Lymphocyte Subsets*
Pregnancy / blood*,  immunology
Reference Values
T-Lymphocytes / immunology
Reg. No./Substance:
0/Antigens, CD56; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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