Document Detail

Changes in lymphocyte status and responsiveness in pregnancy detected by a fluorescent cell probe.
MedLine Citation:
PMID:  3863586     Owner:  NLM     Status:  MEDLINE    
Lymphocyte reactivity assessed by a fluorescent lipophilic probe test of responsiveness to concanavalin A (con A) was shown to differ from normal in early pregnancy. The difference was most marked in multiparas. Abnormal reactivity was detected in the earliest pregnancy examined (5 weeks' gestation) and up to about the 20th week; after 20 weeks, reactivity was normal in all of the multiparas and most of the nulliparas studied. However, in pregnancy induced hypertension (PIH), a disorder of late pregnancy, the same responsiveness as in early pregnancy was found. When unstimulated lymphocytes were examined, abnormal reactivity associated with increased fluorescence was observed in early pregnancy and in PIH, compared with normal late pregnancy, reflecting alteration in lymphocyte membrane phospholipids. It is postulated that pregnancy is associated with sequential change in immunity, disturbance of which may result in immunologically-determined obstetric morbidity.
J M Rolland; M A Barnett; A F Lampard; R C Nairn; E Pihl; W A Walters; C Wood; M N Cauchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  25     ISSN:  0004-8666     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-11-07     Completed Date:  1985-11-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
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MeSH Terms
Concanavalin A / pharmacology
Fluorescent Dyes*
Hypertension / immunology
Lymphocyte Activation*
Pregnancy Complications, Cardiovascular
Reg. No./Substance:
0/Fluorescent Dyes; 11028-71-0/Concanavalin A

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